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Roger Coulombe JR

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Animal, Dairy and Veterinary Sciences

Toxicology

Professor

Educational Background

PhD, Toxicology/Food Science, (Food Science), Oregon State University, 1983
Aflatoxin Mutagenesis and Metabolism and Dietary Modification in Rainbow Trout
MS, Microbiology, University of Idaho, 1979
BS, Microbiology, University of Idaho


Biography

PhD Oregon State University; NIH-National Research Service Award Research Fellow University of California 1982-1984; Professor USU since 1984; Visiting Professor Murdoch University, Perth Western Australia 1994-1995; Fulbright-Saastamoinen Health Sciences Fellow, University of Kuopio Finland, 2010-2011.

Teaching Interests

Environmental Toxicology ADVS/BIOL/PUBH 5400/6400; Advanced and Molecular Toxicology ADVS 6600; Food Safety FSTX 7000, University of Hong Kong

Research Interests

Molecular toxicology, functional genomics of disease, food safety, mechanisms of carcinogenesis and chemoprevention, air pollution


Contact Information

Go toOffice Location: AGRS 240
DialPhone: 435-797-1598
SendEmail: roger@usu.edu

Awards

Honorary Professor, 2011

The University of Hong Kong

Fulbright-Saastamoinen Health Sciences Award, 2010

U.S. Department of State - Fulbright International Exchange Program; Saastamoinen Foundation (Finland)

Library Faculty Award, 2007

Socrates Honorary Award, 2002

University of Idaho

1999 Highlight Paper, 1999

Toxicology and Applied Pharmacology

Best Presentation, 1986

25th Annual Meeting of the Society of Toxicology

National Research Service Award, 1982

National Institutes of Health

National Research Service Award, 1979

National Institutes of Health

    Publications - Books & Book Chapters

      Book Chapters

    • Riley, R.T, Voss, K.A, Coulombe, R.A, Pestka, J.J, Williams, D.E, (2011). Developing mechanism-based and exposure biomarkers for mycotoxins in animals: Determining Mycotoxins and Mycotoxigenic Fungi in Food and Feed . Woodhead Publishing LTD
    • Guarisco, J.A, Hall, J.O, Coulombe, R.A, (2007). Butylated hydroxytoluene reduces aflatoxin B1 bioavailability and hepatic adduct formation in turkeys. Poisonous Plants: Global Research and Solutions - CAB International, London
    • Coulombe, R.A, Yip, S.M, (2007). Heterologous expression of a cytochrome P450 from turkey liver that activates aflatoxin B1. In Poisonous Plants: Global Research and Solutions - CAB International, London
    • Klein, P.J, Hall, J.O, Coulombe, R.A, (2003). Dietary butulated hydroxytoluene protects against aflatoxicosis in turkeys. Poisonous Plants and Related Toxins (T. Acamovic, C.S. Stewart and T.W. Pennycott eds.)
    • Coulombe, R.A, Rieben, W.K, (2003). Lack of apparent base sequence preference of activated pyrrolizidine alkaloid cross-links with DNA. Poisonous Plants and Related Toxins, (T. Acamovic, C.S. Stewart and T.W. Pennycott eds.)
    • Coulombe, R.A, (2000). Natural Toxins and Chemopreventives in Plants. B. Helferich and C. Winter (eds.) Food Toxicology. CRC Press, Inc., Boca Ra
    • Coulombe, R.A, (1999). Natural Toxins. J.J. Francis, (ed) The Wiley Encyclopedia of Food Science and Technology, 2nd Edition
    • Drew, G.L, Stermitz, F.R, Coulombe, R.A, (1998). Molecular Interactions of Pyrrolizidine Alkaloids with critical cellular targets. In T. Garland and A. C. Barr (eds.) Toxic Plants and other Natural Toxicants
    • Sharma, R.P, Coulombe, R.A, (1996). Pharmacokinetics in Risk Assessment. Chapter 7, In: A.M. Fan and L.W. Chang (eds.) Toxicology Risk Assessment
    • Coulombe, R.A, (1994). Non-Hepatic Effects and Biotransformations of Aflatoxin B1. In: D.L. Eaton, and J.D. Groopman (eds.) The Toxicology of Aflatoxins: Human Health, Veterinary and Agricultural Significance
    • Coulombe, R.A, Kim, H.Y, Stermitz, F.R, (1994). Structure-activity relationships of pyrrolizdine alkaloid DNA cross-links. In: S.M. Colegate and P.R. Dorling (eds.) Poisonous Plants of the World: Agricultural, Phytochemical and Ecological Aspects
    • Coulombe, R.A, (1991). Aflatoxins. In: R.P. Sharma and D.K. Salunke (eds.) Mycotoxins and Phytoalexins in Human and Animal Health
    • Coulombe, R.A, (1991). Alternaria Toxins. In: R.P. Sharma and D.K. Salunke (eds.) Mycotoxins and Phytoalexins in Human and Animal Health
    • Coulombe, R.A, Reif, D.W, Keller, R.J, Briskin, D.P, Aust, S.D, Thornley, W.R, Sharma, R.P, (1989). Vanadate stimulation of pyridine nucleotide oxidation in mammalian liver microsomal membranes. In: Simic, M.G., K.A. Taylor, J.F. Ward and C. von Sontag, (eds.) Oxygen Radicals in Biology and Medicine

    * Has not been peer reviewed

    Publications - Fact Sheets

    • Martin, R.S, Coulombe, R.A, Brain, R., (2016). Utah Air Quality: PM2.5. Utah State Univesity Extension Sustainability

    * Has not been peer reviewed

    Publications - Curriculum

      * Has not been peer reviewed

      Publications - Journal Articles

        Academic Journal

      • Monson, M.S, Settlage, R.E, Mendoza, K.M, Rawal, S., El-Nezami, H., Coulombe, R.A, Reed, K.M, , (2015). Modulation of the Spleen Transcriptome in Domestic Turkey (Meleagris gallopavo) in Response to Aflatoxin B1 and Probiotics.. Immunogenetics, 67:3, 163-178. doi: doi: 10.1007/s00251-014-0825-y
      • Monson, M.S, Settlage, R.E, McMahon, K.W, Mendoza, K.M, Rawal, S., El-Nezami, H.S, Coulombe, R.A, Reed, K.M, (2014). Response of the hepatic transcriptome to aflatoxin B1 in domestic turkey (Meleagris gallopavo).. PlOS ONE, 9:6, e100930. doi: doi: 10.1371/journal.pone.0100930
      • Wu, Y., McEwen, G.D, Tang, M., Yu, T., Dimmick, J.T, Zhou, A., Gilbertson, T.A, Coulombe, R.A, Stevens, J.R, (2013). Sensing biophysical alterations of human lung epithelial cells (a549) in the context of toxicity effects of diesel exhaust particles. Cell biochemistry and biophysics, 67:3, 1147-56.
      • Wu, Y., McEwen, G., Tang, M., Dimmick, J., Gilbertson, T.A, Zhou, A., Coulombe, R.A, Stevens, J.R, (2013). Sensing Biophysical Alterations of Human Lung Cells (A549) in the Context of Toxicity Effects of Diesel Exhaust Particles. , 67:3, 1147-1156. doi: doi: 10.1007/s12013-013-9618-4
      • Bunderson, B., June, K., Amanda, C., Kent, R., Coulombe, R.A, (2013). Heterologous Expression and functional characterization of avian Mu-class Glutatione S-transferases. . Comparative Biochemistry and Physiology C Pharmacol Toxicol, 158:2, doi: doi: 10.1016/j.cbpc.2013.05.007
      • Watterson, T., Hamilton, B., Martin, R.S, Coulombe, R.A, (2012). Urban Particulate Matter Activates Akt in Human Lung Cells. Archives of Toxicology, 86:1, 121-35. doi: DOI: 10.1007/s00204-011-0739-5
      • Baldwin, T.T, Riley, R., Zitomer, N.C, Voss, K., Coulombe, R.A, Pestka, J., Williams, D., Glenn, A.E, (2011). The current state of mycotoxin biomarker development in humans and animals and the potential for application to plant systems. World Mycotoxin Forum Journal, 4:3, 257-270.
      • Kim, J., Bunderson, B., Croasdell, A., Coulombe, R.A, (2011). Functional Characterization of Alpha-class Glutathione S-transferases from the Turkey (Meleagris gallopavo) . Toxicological Sciences, 124, 45-53. doi: doi: 10.1093/toxsci/kfr212
      • Rawal, S., Coulombe, R.A, (2011). Metabolism of Aflatoxin B1 in Turkey Liver Microsomes: The Relative Roles of Cytochromes P450 1A5 and 3A34. Toxicology and Applied Pharmacology, 254:3, 349-354. doi: doi:10.1016/j.taap.2011.05.010
      • Dalloul, R., Coulombe, R.A, (2010). Multi-platform next-generation sequencing of the domestic turkey (Meleagris gallopavo) genome assembly and analysis.. PLoS Biology, 8:9, 1-21. doi: 10.1371/journal.pbio.1000475
      • Coulombe, R.A, (2009). Comparative Genomics Identifies New Alpha Class Genes within the Avian Glutathione Stransferase. Gene, in press.
      • Rawal, S., Mendoza , K.M, Reed, K.M, Coulombe, R.A, (2009). Structure, function, and genetic mapping of the Cytochrome P4503A37 gene in the turkey (Meleagris gallopavo).. Cytogenetics and Genome Research, 125, 67-73.
      • Watterson, T.L, Hamilton, B., Martin, R., Coulombe, R.A, (2009). Urban Particulate Matter Causes ER Stress and the Unfolded Protein. Toxicological Sciences, 112, 111-122.
      • Guarisco, J.A, Hall, J.O, Coulombe, R.A, (2008). Butylated hydroxytoluene chemoprevention of aflatoxicosis - effects on aflatoxin B1 bioavailability, hepatic DNA adduct formation, and biliary excretion.. Food and Chemical Toxicology, 46, 3727-3731. doi: 10.1016/j.fct.2008.09.050
      • Coulombe, R.A, Guarisco, J.A, Hall, J.O, (2008). Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis - inhibition of aflatoxin B1 metabolism.. Toxicology and Applied Pharmacology, 227, 339-346. doi: 10.1016/j.taap.2007.11.017
      • Coulombe, R.A, (2007). Mechanisms of Butylated Hydroxytoluene Chemoprevention of Aflatoxicosis - Inhibition of Aflatoxin B1 Metabolism. Toxicology and Applied Pharmacology, (in press)
      • Watterson, T.L, Sorenson, J., Martin, R., Coulombe, R.A, (2007). Effects of PM2.5 Collected from Cache Valley Utah on Genes Associated with the Inflammatory Response in Human Lung Cells. Journal of Toxicology and Environmental Health, 70, 1731-1734. doi: 10.1080/15287390701457746
      • Reed, K.M, Mendoza, K.M, Coulombe, R.A, (2007). Structure and genetic mapping of the Cytochrome P4501A5 gene in the turkey (Meleagris gallopavo). Cytogenetics and Genome Research, 116, 104-109. doi: 10.1159/000097426
      • Van Vleet, T.R, Watterson, T.L, Klein, P.J, Coulombe, R.A, (2006). Aflatoxin B1 Alters the Expression of p53 in CytochromeP450-Expressing Human Lung Cells. Toxicological Sciences, 89, 399-407.
      • Yip, S.S, Coulombe, R.A, (2006). Molecular Cloning and Expression of a Novel Cytochrome P450 from Turkey Liver with Aflatoxin B1 Oxidizing Activity. Chemical Research in Toxicology, 19, 30-37.
      • Coulombe, R.A, Guarisco, J.A, Klein, P.J, Hall, J.O, (2005). Chemoprevention of aflatoxicosis in poultry by dietary butylated hydroxytoluene. Animal Feed Science and Technology, 121, 217-225.
      • Rieben, W.K, Coulombe, R.A, (2004). DNA cross-linking by dehydromonocrotaline lacks apparent base sequence preference. Toxicological Sciences, 82, 497-503.
      • Coulombe, R.A, Klein, P.j, Hall, J.O, (2003). Butylated hydroxytoluene chemoprotection: Response to Williams. Toxicology and Applied Pharmacology, 189, 152.
      • Klein, P.j, Van Vleet, T.R, Hall, J.O, Coulombe, R.A, (2003). Effect of dietary buylated hydroxytoluene on aflatoxin B1-relevant metabolic enzymes in turkeys. Food and Chemical Toxicology, 41, 671-678.
      • Coulombe, R.A, (2003). Pyrrolizidine Alkaloids in Foods. Advances in Food and Nutrition Research (S.L. Taylor, Ed.). Elsevier Science Ltd, 45, 61-99.
      • Klein, P.J, Van Vleet, T.R, Hall, J.O, Coulombe, R.A, (2002). Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B1. Comparative Biochemistry and Physiology, 132, 193-201.
      • Van Vleet, T.R, Mace, K., Coulombe, R.A, (2002). Comparative Aflatoxin B1 Activation and Cytotoxicity in Human Bronchial Cells Expressing Human CYPs 1A2 and 3A4. Cancer Research, 62, 105-112.
      • Klein, P.J, Van Vleet, T.R, Hall, J.O, Coulombe, R.A, (2002). Dietary butylated hydroxytoluene protects against aflatoxicosis in turkeys. Toxicology and Applied Pharmacology, 182, 19-Nov.
      • Van Vleet, T.R, Klein, P.J, Coulombe, R.A, (2002). Metabolism and cytotoxicity of aflatoxin B1 in cytochrome P-450-expressing human lung cells. J. Toxicology and Environmental Health, Part A, 65, 853-67.
      • Van Vleet, T.R, Bombick, D.W, Coulombe, R.A, (2001). Inhibtition of Human Cytochrome P450 2E1 Activity by Nicotine, Cotinine, and Aqueous Cigarette Tar Extract in vitro. Toxicological Sciences, 64, 185-191.
      • Van Vleet, T.R, Klein, P.J, Coulombe, R.A, (2001). Metabolism of Aflatoxin B1 by Normal Human Bronchial Epithelial Cells. J. Toxicology and Environmental Health, Part A, 63, 525-40.
      • Klein, P.K, Kelly, J.N, Buckner, R., Coulombe, R.A, (2000). Biochemical basis for the extreme sensitivity of poultry to aflatoxin B1. Toxicology and Applied Pharmacology, 165, 45-62.
      • Kim, H.Y, Stermitz, F.R, Li, J.K, Coulombe, R.A, (1999). Comparative DNA cross-linking by activated pyrrolizidine alkaloids. Food and Chemical Toxicology, 37, 619-625.
      • Coulombe, R.A, Drew, G.L, Stermitz, F.R, (1999). Pyrrolizidine Alkaloids Cross-Link DNA with Actin. Toxicology and Applied Pharmacology, named 'Highlight Article', 154, 198-202.
      • Stegelmeier, B.L, Edgar, J.A, Colegate, S.M, Gardner, D.L, Schoch, T.K, Coulombe, R.A, Molyneux, R.J, (1999). Pyrrolizidine Alkaloids Plants, Metabolism and Toxicity. Journal of Natural Toxins, 8, 95-116.
      • Coulombe, R.A, (1997). Aflatoxin B1 Activation in Human Lung. Toxicology and Applied Pharmacology, 144, 88-95.
      • Ball, R.W, Huie, J.M, Coulombe, R.A, (1995). Comparative activation of aflatoxin B1 by mammlian pulmonary tissues. Toxicology Lett., 75, 119-125.
      • Coulombe, R.A, Sharma, R.P, Huggins, J.W, (1995). Pharmacokinetics of the antiviral agent 3-dezaneplanocin A.. European J. of Pharmacology and Pharmacokinetics, 20, 197-202.
      • Kim, H.Y, Stermitz, F.R, Coulombe, R.A, (1995). Pyrrolizidine alkaloid-induced DNA-protein cross-links. Carcinogenesis, 16, 2691-2697.
      • Coulombe, R.A, (1993). Biological Action of Mycotoxins. J. Dairy Sci., 76, 880-891.
      • Coulombe, R.A, Huie, J.M, Sharma, R.P, Huggins, J.W, (1993). Pharmacokinetics of the antiviral agent carbocyclic 3-deazaadenosine. Drug Metab. Dispos., 21, 555-559.
      • Kim, H.Y, Stermitz, F.R, Wilson, D.W, Taylor, D., Coulombe, R.A, (1993). Structural influences on pyrrolizidine alkaloid induced cytopathology. Toxicol. Appl. Pharmacol., 122, 61-69.
      • Hsieh, G.C, Sharma, R.P, Parker, R.D, Coulombe, R.A, (1992). Immunological and neurobiochemical alterations induced by repeated oral exposure of phenol in mice. Eur. J. Pharmacol., 228, 107-114.
      • Coulombe, R.A, (1991). Comparative metabolism of aflatoxin B1 in mammalian upper airway epithelium. Carcinogenesis, 12, 305-310.
      • Coulombe, R.A, Hincks, J.R, Kim, H.Y, Segall, H.J, Molyneaux, R.J, Stermitz, F.R, (1991). DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: structure-activity relationships. Toxicol. Appl. Pharmacol., 111, 90-98.
      • Coulombe, R.A, Huie, J.M, Ball, R.W, Sharma, R.P, Wilson, D.W, (1991). Pharmacokinetics of Intratracheally-Administered Aflatoxin B1. Toxicol. Appl. Pharmacol., 109, 196-206.
      • Wilson, D.W, Ball, R.W, Coulombe, R.A, (1990). Comparative action of aflatoxin B1 in tracheal explants from four mammalian species. Cancer Res., 50, 2493-2498.
      • Ball, R.W, Coulombe, R.A, (1990). Comparative formation and repair of aflatoxin B1-DNA adducts in mammalian tracheal epithelium. Cancer Res., 50, 4918-4922.
      • Hsieh, G.C, Sharma, R.P, Parker, R.D, Coulombe, R.A, (1990). Evaluation of toluene exposure via drinking water levels of regional brain biogenic amines and their metabolites in CD-1 mice. Ecotoxicol. Environ. Safety, 20, 175-184.
      • Huie, J.M, Sharma, R.P, Coulombe, R.A, (1989). Diurnal alterations in regional brain catecholamines and indoleamines in the CD-1 mouse. Comp. Biochem. Physiol., 94C, 575-579.
      • Keller, R.J, Coulombe, R.A, Sharma, R.P, Grover, T.A, Piette, L.H, (1989). Importance of hydroxyl radical in the vanadium-stimulated oxidation of NADH. Free Rad. Biol. Med., 6, 15-22.
      • Flora, S.J, Coulombe, R.A, Sharma, R.P, Tandon, S.K, (1989). Influence of dietary protein deficiency on lead-copper interaction in rats. Ecotox. Environ. Safety, 18, 75-82.
      • Keller, R.J, Coulombe, R.A, Sharma, R.P, Grover, T.A, Piette, L.H, (1989). Oxidation of NADH by vanadium in the presence of thiols. Arch. Biochem. Biophys., 271, 40-48.
      • Hincks, J.R, Coulombe, R.A, (1989). Rapid analysis of DNA-DNA and DNA protein cross-links by gravity-flow alkaline elution. Environ. Molec. Mutagen, 13, 211-217.
      • Reif, D.W, Coulombe, R.A, Aust, S.D, (1989). Vanadate Dependent NAD(P)H Oxidation by Microsomal Enzymes. Arch. Biochem. Biophys., 270, 137-143.
      • Bailey, G.S, Williams, D.E, Wicox, J.S, Loveland, P.M, Coulombe, R.A, Hendricks, J.D, (1988). Aflatoxin B1 carcinogenesis and its relationship to DNA adduct formation and adduct persistence in sensitive and resistant salmonid fish. Carcinogenesis, 9, 1919-1926.
      • Jayasekara, S., Drown, D.B, Coulombe, R.A, Sharma, R.P, (1988). Alteration of biogenic amines in mouse brain regions by alkylating agents I. Effects of aflatoxin B1 (AFB1) on brain concentrations of monoamines and activities of metabolizing enzymes. Arch. Environ. Contam. Toxicol., 18, 396-403.
      • Margaretten, N.C, Hincks, J.H, Warren, R.P, Coulombe, R.A, (1987). Effects of phenytoin and carbamazepine in human natural killer cell activity and genotoxicity in vitro. Toxicol. Appl. Pharmacol., 87, 10-17.
      • Sharma, R.P, Coulombe, R.A, (1987). Effects of repeated doses of aspartame on serotonin and its metabolite in various mouse brain regions. Food Chem. Toxicol., 25, 565-568.
      • Coulombe, R.A, Briskin, D.P, Keller, R.J, Thornley, W.R, Sharma, R.P, (1987). Vanadate-dependent oxidation of pyridine nucleotides in rat liver microsomal membranes. Archives Biochem. Biophys., 255, 267-273.
      • Sharma, R.P, Coulombe, R.A, Srisuchart, B., (1986). Effects of dietary vanadium exposure on regional brain neurotransmitter levels and their metabolites. Biochem. Pharmacol., 35, 461-465.
      • Hincks, J.R, Coulombe, R.A, (1986). Gravity-flow alkaline elution: a method to rapidly detect carcinogen-induced DNA strand breaks. Biochem. Biophys. Res. Commun., 137, 1006-1014.
      • Coulombe, R.A, Wilson, D.W, Hsieh, D.P, Plopper, C.G, Serabjit-Singh, C.J, (1986). Metabolism of aflatoxin B1 in the upper airways of the rabbit: the role of the non-ciliated tracheal epithelial cell. Cancer Res., 46, 4091-4096.
      • Coulombe, R.A, (1986). Neurotoxic Potential of the Artificial Sweetener Aspartame. Toxicol. Appl. Pharmacol., 83, 79-85.
      • Coulombe, R.A, (1985). Aflatoxin B1-induced alterations in brain amine synthesis in rats. Toxicol. Appl. Pharmacol., 80, 496-501.
      • Coulombe, R.A, (1985). Pharmacokinetics of intratracheally and orally administered aflatoxin B1 in the rat. Food Chem. Toxicol., 23, 827-830.
      • Coulombe, R.A, Bailey, G.S, Nixon, J.E, (1984). Comparative activation of aflatoxin B1 to mutagens by isolated hepatocytes from rainbow trout (Salmo gairdneri) and coho salmon (Oncorynchus kisutch). Carcinogenesis, 5, 29-33.
      • Shelton, D.W, Hendricks, J.D, Coulombe, R.A, Bailey, G.S, (1984). Effect of dose on the inhibition of carcinogenesis/mutagenesis by Aroclor 1254 in the rainbow trout fed aflatoxin B1.. J. Toxicol. Environ Health, 13, 649-657.
      • Eisele, T.A, Coulombe, R.A, Pawlowski, N.E, Nixon, J.E, (1984). Effect of route of exposure and combined exposure of mixed-function oxidase inducers and supressors on hepatic parameters in rainbow trout (Salmo gairdneri). Aquatic Toxicol., 5, 211-216.
      • Coulombe, R.A, Wilson, D.W, Hsieh, D.P, (1984). Metabolism, DNA binding and cytotoxicity of aflatoxin B1 in tracheal explants from Syrian hamsters. Toxicology, 32, 117-130.
      • Gillett, J.W, Knittel, M.D, Jolma, E., Coulombe, R.A, (1983). Applicability of microbial toxicity assays to assessment problems. Environ. Toxicol. and Chem., 2, 185-193.
      • Loveland, P.M, Coulombe, R.A, Libbey, L.M, Pawlowski, N.E, Sinnhuber, R.O, Nixon, J.E, (1983). Identification and mutagenicity of aflatoxicol M1 produced by metabolism of aflatoxin B1 and aflatoxicol by liver fractions from rainbow trout (Salmo gairdneri). Food Chem. Toxicol., 21, 557-562.
      • Shelton, D.W, Coulombe, R.A, Hindricks, J.E, (1983). Inhibitory effect of Aroclor 1254 on aflatoxin-initiated carcinogenesis in rainbow trout and mutagenesis using a Salmonella/trout hepatic activation system. Aquatic Toxicol., 3, 229-238.
      • Eisele, T.A, Coulombe, R.A, Williams, J.L, Shelton, D.W, Nixon, J.E, (1983). Time and dose-dependent effects of dietary cyclopropenoid fatty acids on the mixed-function oxidase system of rainbow trout. Aquatic Toxicol., 4, 139-151.
      • Coulombe, R.A, Shelton, D.W, Sinnhuber, R.O, Nixon, J.E, (1982). Comparative mutagenicity of aflatoxins using a Salmonella/trout hepatic activation system. Carcinogenesis, 3, 1261-1264.
      • Pollock, G.A, DiSabotino, C.E, Heimsch, R.C, Coulombe, R.A, (1982). Distribution, elimination and metabolism of 14C-alternariol monomethylether in the rat. J. Environ. Sci. Health B, 17, 109-124.
      • In-House Journal

      • Coulombe, R.A, (2015). We're Number 1: Air Pollution in Utah. Cultivate, Winter *
      • Professional Journal

      • Monson, M.S, Cardona, C.C, Reed, K.M, Coulombe, R.A, (2016). Hepatic transcriptome responses of domestic and wild turkey embryos to aflatoxin B. Toxins, 8:16, 1-22. doi: doi:10.3390/toxins8010016
      • Monson, M.S, Coulombe, R.A, Reed, K.M, (2015). Aflatoxicosis: Lessons from toxicity and responses to aflatoxin B1 in poultry. . Agriculture - Special Edition on Nutritional Toxicology and Animal Nutrition, 5:3, 742-777. doi: DOI: 10.3390/agriculture5030742
      • Rawal, S., Bauer, M.M, Mendoza, K.M, El-Nezami, H., Hall, J.O, Kim, J.E, Stevens, J.R, Reed, K.M, Coulombe, R.A, (2014). Aflatoxicosis chemoprevention by probiotic Lactobacillius and lack of effect on the major histocompatibility complex. Research Veterinary Science, 97:2, 274-281. doi: doi: 10.1016/j.rvsc.2014.06.008
      • Kim, J.E, Bauer, M.M, Mendoza, K.M, Reed, K.M, Coulombe, R.A, (2010). Comparative Genomics Identifies New Alpha Class Genes within the Avian Glutathione S-transferase Gene Cluster (Meleagris gallopavo). Gene, 452, 45-53. doi: doi:10.1016/j.gene.2009.11.001
      • Rawal, S., Kim, J., Coulombe, R.A, (2010). Aflatoxin in poultry: metabolism, toxicity, and prevention. Research in Veterinary Science , 89, 325-331.
      • Rawal, S., Yip, S.S, Coulombe, R.A, (2010). Cloning, expression and functional characterization of cytochrome P450 3A37 from Turkey Liver with Aflatoxin B1 Epoxidation Activity. Chemical Research in Toxicology , 23, 1322-1329. doi: DOI: 10.1021/tx1000267
      • Kelly, J.D, Guengerich, F.P, Eaton, D.L, Coulombe, R.A, (1997). Activation of aflatoxin B1 by human lung. Toxicology and Applied Pharmacology, 144, 88-95.
      • Coulombe, R.A, (1996). Does nature know best? Natural carcinogens and anticarcinogens in American food. American Council on Science and Health
      • Ball, R.W, Coulombe, R.A, (1991). Comparative biotransformation of aflatoxin B1 in mammalian upper airway epithelium. Carcinogenesis , 12, 305-310.
      • Coulombe, R.A, Sharma, R.P, (1986). Neurobiochemical alterations induced by the artificial sweetener aspartame (NutraSweet«). Toxicol. Appl. Pharmacol, 83, 79-85.
      • Coulombe, R.A, Sharma, R.P, (1985). Clearance and excretion of intratracheally and orally administered aflatoxin B1 in the rat. Food Chem. Toxicol, 23, 827-830.
      • Coulombe, R.A, (1985). Effect of repeated dietary exposure of aflatoxin B1 on brain biogenic amines amines and metabolites in rats. Toxicol. Appl. Pharmacol, 80, 496-501.

      * Has not been peer reviewed

      Publications - Literary Journal

        * Has not been peer reviewed

        Publications - MultiMedia

          * Has not been peer reviewed

          Publications - Technical Reports

            * Has not been peer reviewed

            Publications - Translations & Transcripts

              Publications - Other

              * Has not been peer reviewed

              Scheduled Teaching

              FSTX 7002 - School of Biological Sciences, University of Hong Kong Food Toxicology, Fall 2017

              ADVS, BIOL, PUBH 5400, 6400 - Environmental Toxicology, Spring 2017

              ADVS 6810 - Seminar in Toxicology, Spring 2017

              ADVS 6600 - Advanced and Molecular Toxicology, Fall 2016

              FSTX 7002 - School of Biological Sciences, University of Hong Kong Food Toxicology, Fall 2016

              ADVS, BIOL, PUBH 5400, 6400 - Environmental Toxicology, Spring 2016

              ADVS 6810 - Seminar in Toxicology, Spring 2016

              FSTX 7002 - School of Biological Sciences, University of Hong Kong Food Toxicology, Fall 2015

              ADVS,BIOL,PUBH 5400,6400 - Environmental Toxicology, Spring 2015

              ENGR 5670 - HAZWOPER, Spring 2015

              ADVS 6810 - Seminar in Toxicology, Spring 2015

              ADVS 6600,7600 - Advanced and Molecular Toxicology, Fall 2014

              FSTX 7002 - School of Biological Sciences, University of Hong Kong Food Toxicology, Fall 2014

              ADVS,BIOL,PUBH 5400,6400 - Environmental Toxicology, Spring 2014

              ADVS 6810 - Seminar in Toxicology, Spring 2014

              FSTX 7002 - School of Biological Sciences, University of Hong Kong Food Toxicology, Fall 2013

              ADVS,BIOL,PUBH 5400,6400 - Environmental Toxicology, Spring 2013

              ENGR 5670 - HAZWOPER, Spring 2013

              ADVS 6810 - Seminar in Toxicology, Spring 2013

              FSTX 7002 - School of Biological Sciences, University of Hong Kong Food Toxicology, Fall 2012

              ADVS,BIOL,PUBH 5400,6400 - Environmental Toxicology, Spring 2012

              ENGR 5670 - HAZWOPER, Spring 2012

              ADVS 6600 - Advanced and Molecular Toxicology, Fall 2011

              FSTX 7002 - School of Biological Sciences, University of Hong Kong Food Toxicology, Fall 2011

              ADVS/BIOL/PUBH 5400/6400 - ENVIRON TOXICOLOGY, Spring 2011

              ENGR 5670 - HAZWOPER, Spring 2011

              FSTX 7002 - School of Biological Sciences, University of Hong Kong Food Toxicology, Fall 2010

              Food and Nutritional Toxicology Lecture Series: Risk Assessment of Enivonmental and Food Contaminants, Summer 2010

              ADVS/BIOL 5400 - Environmental Toxicology , Spring 2010

              ADVS/PUBH/BIOL 5400 - Environmental Toxicology, Spring 2010

              ENGR 5670 - HAZWOPER, Spring 2010


              Graduate Students Mentored

              Teresa Allpress, Animal, Dairy and Veterinary Sciences, June 2010
              Brett Bunderson, Animal, Dairy and Veterinary Sciences, January 2010
              Todd Watterson, Animal, Dairy and Veterinary Sciences, May 2006
              Sumit Rawal, Animal, Dairy and Veterinary SciencesMay 2010
              John Guarisco, Animal, Dairy and Veterinary SciencesMay 2007
              Patrick Klein, Animal, Dairy and Veterinary SciencesMay 2002
              Terry VanVleet, Animal, Dairy and Veterinary Sciences 2001
              Michael Eichelberger, Animal, Dairy and Veterinary Sciences 1998
              Gail Drew, Animal, Dairy and Veterinary SciencesMay 1997
              Hea-Young Kim, Animal, Dairy and Veterinary SciencesMay 1994
              R. Wayne Ball, Animal, Dairy and Veterinary SciencesMay 1989
              Jeffrey R. Hincks, Animal, Dairy and Veterinary Sciences 1987