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Don Smee

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Animal, Dairy and Veterinary Sciences

Virology, Antiviral Research, Influenza, Emerging Viruses, Cell Culture Models, Mouse Models

Research Professor

Educational Background

PhD, Virology, (Microbiology), Utah State University, 1981
MS, Virology, (Microbiology), Utah State University, 1979
BA, Biology, (Military Science (ROTC)), University of Utah, 1974




Research Interests

Influenza virus, pox virus, rodent models, cell culture, biochemical assays


Contact Information

Office Hours: 8:00 a.m. to 5:00 p.m.
Go toOffice Location: VSB 301
DialPhone: 435-797-2897
SendEmail: don.smee@usu.edu

Awards

James LeGrand Shupe Achievement Award, 2007

Served on grant review study sections, 2002

Outstanding Researcher in the College of Agriculture, 2001

Visiting Scientist, 1996


    Publications - Books & Book Chapters

      Book Chapters

    • Smee, D., Barnard, D., (2013). Methods for evaluation of antiviral efficacy against influenza virus infections in animal models. Methods in Molecular Biology
    • Smee, D., (2006). Development of antiviral drugs against avian (H5N1) influenza virus.. In: J.P. Wong (Ed.), Recent Developments on the Avian Influenza (H5N1) Crisis. Transworld Research Network, Kerala, India

    * Has not been peer reviewed

    Publications - Fact Sheets

      * Has not been peer reviewed

      Publications - Curriculum

        * Has not been peer reviewed

        Publications - Journal Articles

          Academic Journal

        • Smee, D., Evans, J., Nicolaou, K.C, Tarbet, B., Day, C.W, (2016). Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds. Antiviral Research, 131, 61-65.
        • Westover, J.B, Sefing, E.J, Bailey, K.W, Van Wettere, A., Jung, K.H, Dagley, A., Wandersee, L., Downs, B., Smee, D., Furuta, Y., Bray, M., Gowen, B., (2016). Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viruses. Antiviral Research
        • Swanson, M.D, Boudreaux, D.M, Salmon, L., Chugh, J., Winter, H.C, Meagher, J.L, Andre, S., Murphy, P.V, Oscarson, S., Roy, R., King, S., Kaplan, M.H, Goldstein, I.J, Tarbet, B., Hurst, B.L, Smee, D., de le Fuente, C., Hoffman, H.H, Xue, Y., Rice, C.M, Schols, D., Garcia, J.V, Stuckey, J.A, Gabius, H.J, Al-Hashimi, H.M, Markovitz, D.M, (2015). Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity. Cell, 163:3, 746-758.
        • Smee, D., Dagley, A., Downs, B., Hagloch, J., Tarbet, B., (2015). Enhanced efficacy of cidofovir combined with vaccinia immune globulin in treating progressive cutaneous vaccinia virus infections in immunosuppressed hairless mice. Antimicrobial Agents and Chemotherapy, 59:1, 520-6.
        • Julander, J.G, Kesler, K., Van Wettere, A., Morrey, J.D, Smee, D., (2014). The use of plethysmography in determining the severity of lung pathology in a mouse model of minimally lethal influenza virus infection. Antiviral Research, 108, 10-13.
        • Julander, J., Kesler, K., Van Wettere, A., Morrey, J.D, Smee, D., (2014). The use of plethysmography in determining the severity of lung pathology in a mouse model of minimally lethal influenza virus infection. Antiviral Research, 108, 10-13. doi: 10.1016/j.antiviral.2014.05.002
        • Tarbet, B., Hamilton, S., Vollmer, A.H, Luttick, A., Ng, W., Pryor, M., Hurst, B.L, Crawford, S., Smee, D., Tucker, S., (2014). A zanamivir dimer with prophylactic and enhanced therapeutic activity against influenza viruses. Journal of Antimicrobial Chemotherapy, 69:8, 2164-2174.
        • Tarbet, B., Vollmer, A.H, Hurst, B.L, Barnard, D., Furuta, Y., Smee, D., (2014). In vitro activity of favipiravir and neuraminidase inhibitor combinations against oseltamivir-sensitive and oseltamivir-resistant pandemic influenza A (H1N1) virus. Archives of Virology, 159:6, 1279-1291.
        • Smee, D., Hurst, B.L, Day, C.W, Geiben-Lynn, R., (2014). Influenza virus H1N1 inhibition by serine protease inhibitor (serpin) antithrombin III. International Trends in Immunology, 2:2, 83-86.
        • Wu, C.C, Crain, B., Yao, S., Sabet, M., Lao, F.S, Tawatao, R., Chan, M., Smee, D., Julander, J., Cottam, H.B, Guiney, D.G, Corr, M., Carson, D.A, Hayashi, T., (2014). Innate immune protection of infectious disease by pulmonary administration of phospholipid conjugated TLR7 ligands. Journal of Innate Immunity, 6:3, 315-324.
        • Gowen, B., Jung, K., Sefing, E.J, Wong, M., Westover, J.B, Smee, D., (2014). Activity of a phenolic dibenzylsulfide against New World arenavirus infections. Antiviral Chemistry & Chemotherapy, 23:4, 151-159.
        • Krajczyk, A., Kulinska, K., Kulinski, T., Hurst, B.L, Day, C.W, Smee, D., Ostrowski, T., januszczyk, P., Zeidler, J., (2014). Antivirally active ribavirin analogues - 4,5-disubstituted 1,2,3-triazole nucleosides: biological evaluation against certain respiratory viruses and computational modelling. Antiviral Chemistry & Chemotherapy , 23:4, 161-171.
        • Furuta, Y., Gowen, B., Takahashi, K., Shiraki, K., Smee, D., Barnard, D., (2013). Favipiravir (T-705), a novel viral RNA polymerase inhibitor. Antiviral Research, 100:2, 446-454.
        • Smee, D., (2013). Synergistic combinations of favipiravir and oseltamivir against wild-type pandemic and oseltamivir-resistant influenza A (H1N1) virus infections in mice. Future, 8:11, 1085-1094.
        • Smee, D., Tarbet, B., Furuta, Y., Morrey, J.D, Barnard, D., (2013). Synergistic combinations of favipiravir and oseltamivir against wild-type pandemic and oseltamivir-resistant influenza A virus infections in mice. Antiviral Research, 8:11, 1085-1094.
        • Smee, D., (2013). Orthopoxvirus inhibitors that are active in animal models: an update from 2008 to 2012. Future Virology, 8:9, 891-901.
        • Smee, D., (2013). Effects of nasal or pulmonary delivered treatments with an adenovirus vectored interferon (mDEF201) on respiratory and systemic infections in mice caused by cowpox and vaccinia viruses. PLoS One, 8:7, e68685.
        • Nguyen, J.T, Smee, D., Barnard, D., Julander, J., Gross, M., De Jong, M., Went, G.T, , , (2012). Efficacy of combined therapy with amantadine, oseltamivir, and ribavirin in vivo against susceptible and amantadine-resistant influenza A viruses. PLoS ONE , 7(1): e31006, doi: 10.1371/journal.pone.0031006
        • Murray, J.L, McDonald, N.J, Sheng, J., Shaw, M.W, Hodge, T.W, Rubin, D.H, O'Brien, W.A, Smee, D., (2012). Inhibition of influenza A virus replication by antagonism of a PI3K-AKT-mTOR pathway member identified by gene-trap insertional mutagenesis. Antiviral Chemistry & Chemotherapy, 22, 205-215.
        • Smee, D., Julander, J., Tarbet, B., Gross, M., Nguyen, J., (2012). Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents. Antiviral Research, 96, 13-20.
        • Tarbet, B., Maekawa, M., Furuta, Y., Babu, Y., Morrey, J.D, Smee, D., (2012). Combinations of Favipiravir and Peramivir for the Treatment of Pandemic Influenza A/California/04/2009 (H1N1) Virus Infections in Mice. . Antiviral Research, 94:(1), 103-110.
        • Nicolaou, K.C, Lu, M., Totokotsopoulos, S., Heretsch, P., Giguere, D., Sun, Y., Sarlah, D., Nguyen, T.H, Wolf, I.C, Smee, D., Day, C.W, Bopp, S., Winzeler, E.A, (2012). Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents. Journal of the American Chemical Society, 134, 17320-17332.
        • Smee, D., von Itzstein, M., Bhatt, B., Tarbet, B., (2012). Exacerbation of Influenza Virus Infections in Mice by Intranasal Treatments and Implications for Evaluation of Antiviral Drugs. Antimicrobial Agents and Chemotherapy, 56, 6328-6333.
        • Kumaki, Y., Craig, D., Morrey, J.D, Smee, D., Barnard, D., (2011). In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections. . Antiviral Research/Elsevier, 92:2, 329-340.
        • Julander, J., Hagloch, J., Latimer, S., Motter, N., Dagley, A., Barnard, D., Smee, D., Morrey, J.D, (2011). Use of plethysmography in assessing the efficacy of antivirals in a mouse model of pandemic influenza A virus. Antiviral Research, 92:2, 228-36.
        • Mendenhall, M., Russell, A., Smee, D., Hall, J.O, Skirpstunas, R., Furuta, Y., Gowen, B., (2011). Effective oral favipiravir (T-705) therapy initiated after the onset of clinical disease in a model of arenavirus hemorrhagic Fever. PLoS Negl. Trop. Dis., 5:10, e1342.
        • Smee, D., Hurst, B.L, Wong, M., (2011). Effects of TheraMax on influenza virus infections in cell culture and in mice . Antivir. Chem. Chemother., 21, 231-237.
        • Smee, D., Bailey, K.W, Wong, M., Tarbet, E.B, (2011). Topical treatment of cutaneous vaccinia virus infections in immunosuppressed hairless mice with selected antiviral substances . Antivir. Chem. Chemother., 21, 201-208.
        • Buys, K.K, Jung, K., Smee, D., Furuta, Y., Gowen, B., (2011). Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir. Antivir. Chem. Chemother., 21:5, 193-200.
        • Tarbet, E.B, Larson, D., Anderson, B.J, Bailey, K.W, Wong, M., Smee, D., (2011). Evaluation of imiquimod for topical treatment of vaccinia virus cutaneous infections in immunosuppressed hairless mice . Antiviral Res., 90, 126-133.
        • Tarbet, B., Larson, D.P, Andersoon, B.J, Bailey, K.W, Wong, M., Smee, D., (2011). Evaluation of Imiquimod for Treatment of a Vaccinia Virus (WR strain) Cutaneous Infection in Immunosuppressed Mice . Antiviral Research, 90, 126-133.
        • Buys, K.K, Jung, K., Smee, D., Furuta, Y., Gowen, B.B, (2011). Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir . Antivir. Chem. Chemother., 21, 193-200.
        • Kumaki, Y., Wandersee, M.K, Smith, A.J, Zhou, Y., Simmons, G., Nelson, N.M, Bailey, K.W, Vest, Z.G, Li, J.K, Chan, P.K, Smee, D., Barnard, D.L, (2011). Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB/c mouse model by stinging nettle lectin, Urtica dioica agglutinin . Antiviral Res., 90, 22-32.
        • Mendenhall, M., Russell, A., Juelich, T., Messina, E.L, Smee, D., Freiberg, A.N, Holbrook, M.R, Furuta, Y., de la Torre, J.C, Nunberg, J.H, Gowen, B., (2011). T-705 (Favipiravir) inhibition of arenavirus replication in cell culture. Antimicrob. Agents Chemother., 55:2, 782-787.
        • Maddry, J.A, Chen, X., Jonsson, C.B, Ananthan, S., Hobrath, J., Smee, D., Noah, J.W, Noah, D., Xu, X., Jia, F., Maddox, C., Sosa, M.I, White, E.L, Severson, W.E, (2011). Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen . J. Biomol. Screen, 16, 73-81.
        • Smee, D., Bailey, K.W, Wong, M., Tarbet, B., (2011). Topical Treatment of Cutaneous Vaccinia Virus Infections in Immunosuppressed Hairless Mice with Selected Antiviral Substances . Antiviral Chemistry & Chemotherapy , 21:5, 201-208.
        • Smee, D., Hurst, B.L, Wong, M., Tarbet, B., Babu, Y.S, Klumpp, K., Morrey, J.D, (2010). Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res., 88:1, 38-44.
        • Gowen, B., Wong, M.H, Larson, D., Ye, W., Jung, K.H, Sefing, E.J, Skirpstunas, R., Smee, D., Morrey, J.D, Schneller, S.W, (2010). Development of a new Tacaribe arenavirus infection model and its use to explore antiviral activity of a novel aristeromycin analog. PLoS ONE, 5:9, pii: e12760.
        • Lam, A.M, Murakami, E., Espiritu, C., Steuer, H.M, Niu, C., Keilman, M., Bao, H., Zennou, V., Bourne, N., Julander, J., Morrey, J.D, Smee, D., Frick, D.N, Heck, J.A, Wang, P., Nagarathnam, D., Ross, B.S, Sofia, M.J, Otto, M.J, Furman, P.A, (2010). PSI-7851, a pronucleotide of beta-D-2'-fluro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob. Agents Chemother., 54:8, 3187-3196.
        • Julander, J., Jha, A.K, Choi, J.A, Jung, K.H, Smee, D., Morrey, J.D, Chu, C.K, (2010). Efficacy of 2'-C-methylcytidine against yellow fever virus in cell culture and in a hamster model. Antiviral Res., 86:3, 261-267.
        • Gowen, B., Wong, M., Jung, K., Smee, D., Morrey, J.D, Furuta, Y., (2010). Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models. Antiviral Res., 86:2, 121-127.
        • Rao, J.R, Jha, A.K, Rawal, R.K, Sharon, A., Day, C.W, Barnard, D., Smee, D., Chu, C.K, (2010). (-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 N1N1 (swine flu) . Bioorg. Med. Chem. Lett. , 20:8, 2601-2604.
        • Smee, D., Hurst, B.L, Wong, M., (2010). Lack of efficacy of aurintricarboxylic acid and ethacrynic acid against vaccinia virus respiratory infections in mice. Antiviral Chem. Chemother., 20:5, 201-205.
        • Kumaki, Y., Day, C.W, Bailey, K.W, Wandersee, M.K, Wong, M., Madsen, J.R, Madsen, J.S, Nelson, N.M, Hoopes, J.D, Woolcott, J.D, McLean, T.Z, Blatt, L.M, Salazar, A.M, Smee, D., Barnard, D., (2010). Induction of interferon-gamma-inducible protein 10 by SARS-CoV infection, interferon alfacon 1 and interferon inducer in human bronchial epithelial Calu-3 cells and BALB/c mice. Antiviral chemistry & chemotherapy/International Medical Press, 20:4, 169-177.
        • Nguyen, J.T, Hoopes, J.D, Le, M.H, Smee, D., Patick, A.K, Faix, D.F, Blair, P.J, de Jong, M.D, Prichard, M.N, Went, G.T, (2010). Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro. PLoS One, 5:2, e9332.
        • Selvam, P., Chandramohan, M., Hurst, B.L, Smee, D., (2010). Activity of isatine-sulfadimidine derivatives against 2009 pandemic H1N1 influenza virus in cell culture. Antiviral Chem. Chemother., 20:3, 143-146.
        • Smee, D., Hurst, B.L, Wong, M., Bailey, K.W, Tarbet, B., Morrey, J.D, Furuta, Y., (2010). Effects of combinations of favipiravir (T-705) and oseltamivir on influenza A (H1N1, H3N2, and H5N1) virus infections in mice. Antimicrob. Agents Chemother., 54:1, 126-133.
        • Day, C.W, Baric, R., Cai, S.X, Freeman, M., Kumaki, Y., Morrey, J.D, Smee, D., Barnard, D., (2009). A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo . Virology, 395:2, 210-222.
        • Smee, D., Hurst, B.L, Egawa, H., K.T, Kadota, T., Furuta, Y., (2009). Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells. J. Antimicrob. Chemother. , 64:4, 741-746.
        • Nguyen, J.T, Hoopes, J.D, Smee, D., Prichard, M.N, Driebe, E.M, Engelthaler, D.M, Le, M.H, Keim, P.S, Spence, R.P, Went, G.T, (2009). Triple combination of oseltamivir, amantadine, and ribavirin displays synergistic activity against multiple influenza virus strains in vitro. Antimicrob. Agents Chemother., 53:10, 4115-4126.
        • Julander, J., Smee, D., Morrey, J.D, Furuta, Y., (2009). Effect of T-705 treatment on western equine encephalitis in a mouse model. Antiviral Res., 82:3, 169-171.
        • Furuta, Y., Takahashi, K., Shiraki, K., Sakamoto, K., Smee, D., Barnard, D., Gowen, B., Julander, J., Morrey, J.D, (2009). T-705 (favipiravir) and related compounds: novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res, 82:3, 95-102.
        • Smee, D., Hurst, B.L, Wong, M., Bailey, K.W, Morrey, J.D, (2009). Effects of double combinations of amantadine, oseltamivir, and ribavirin on influenza A (H5N1) virus infections in cell culture and in mice. Antimicrob. Agents Chemother., 53, 2120-2128.
        • Roth, J.P, Li, J.K, Smee, D., Morrey, J.D, Barnard, D., (2009). A recombinant, infectious human parainfluenza virus type 3 expressing the enhanced green fluorescent protein for use in high-throughput antiviral assays. Antiviral Res., 82:1, 12-21.
        • Nair, V., Chi, G., Shu, Q., Julander, J., Smee, D., (2009). A heterocyclic molecule with significant activity against dengue virus. Bioorg. Med. Chem. Lett., 19:5, 1425-1427.
        • Nair, V., Chi, G., Shu, Q., Julander, J., Smee, D., (2009). A heterocyclic molecule with significant activity against dengue virus. Bioorg. Med. Chem. Lett., 19:5, 1425-1427.
        • Julander, J., Shafer, K., Smee, D., Morrey, J.D, Furuta, Y., (2009). Activity of T-705 in a hamster model of yellow fever virus infection in comparison with a chemically related compound T-1106. Antimicrob. Agents Chemother., 53:1, 202-209.
        • Julander, J., Shafer, K., Smee, D., Morrey, J.D, Furuta, Y., (2009). Activity of T-705 in a hamster model of yellow fever virus infection in comparison with a chemically related compound T-1106. Antimicrob. Agents Chemother., 53:1, 202-209.
        • Smee, D., Gowen, B., Wandersee, M.K, Wong, M., Skirpstunas, R., Baldwin, T.J, Hoopes, J.D, Sidwell, R.W, (2008). Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes and effects of cidofovir treatment. International Journal of Antimicrobial Agents, 31, 352-359.
        • Morrey, J.D, Taro, B.S, Siddharthan, V., Wang, H., Smee, D., Christensen, A.J, Furuta, Y., (2008). Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents. Antiviral Res., 80:3, 377-379.
        • Julander, J., Bowen, R.A, Rao, J.R, Day, C., Shafer, K., Smee, D., Morrey, J.D, Chu, C.K, (2008). Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine. Antiviral Res., 80:3, 309-315.
        • Julander, J., Bowen, R.A, Rao, J.R, Day, C., Shafer, K., Smee, D., Morrey, J.D, Chu, C.K, (2008). Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine. Antiviral Res., 80:3, 309-315.
        • Smee, D., Bailey, K.W, Wong, M., O'Keefe, B.R, Gustafson, K.R, Mishin, V.P, Gubareva, L.V, (2008). Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N. Antiviral Res., 80:3, 266-271.
        • Gowen, B., Smee, D., Wong, M., Hall, J.O, Jung, K., Bailey, K.W, Stevens, J.R, Furuta, Y., Morrey, J.D, (2008). Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin. PLoS ONE, 3:11, e3725.
        • Smee, D., (2008). Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antiviral Chem. Chemother., 19:3, 115-124.
        • Smee, D., (2008). Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus. Antiviral Chem. Chemother., 19:3, 15-24.
        • Kumaki, Y., Day, C.W, Wandersee, M.K, Schow, B.P, Madsen, J.S, Grant, D., Roth, J.P, Smee, D., Blatt, L.M, Barnard, D., (2008). Interferon alfacon 1 inhibits SARS-CoV infection in human bronchial epithelial Calu-3 cells. Biochem. Biophys. Res. Commun., 371:1, 110-113.
        • Julander, J., Skirpstunas, R., Siddharthan, V., Shafer, K., Hoopes, J.D, Smee, D., Morrey, J.D, (2008). C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection. Antiviral Res., 78:3, 230-241.
        • Julander, J., Skirpstunas, R., Siddharthan, V., Shafer, K., Hoopes, J.D, Smee, D., Morrey, J.D, (2008). C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection. Antiviral Res., 78:3, 230-241.
        • Smee, D., Gowen, B., Wandersee, M.K, Wong, M., Skirpstunas, R.T, Baldwin, T.J, Hoopes, J.D, Sidwell, R.W, (2008). Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes, and effects of cidofovir treatment. Int. J. Antimicrob. Agents, 31:4, 352-359.
        • Fatemi, S.H, Reutiman, T.J, Folsom, T.D, Huang, H., Oishi, K., Mori, S., Smee, D., Pearce, D.A, Winter, C., Sohr, R., Juckel, G., (2008). Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of schizophrenia. Schizophr. Res., 99:1-3, 56-70.
        • Smee, D., (2007). Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by cell culturing in the presence of the inhibitor. Antiviral Chem. Chemother., 18, 317-327.
        • Smee, D., (2007). Novel-3-sulphonamido-quinazolin-4(3H)-one derivatives: microwave-assisted synthesis and evaluation of anti-viral activities against respiratory and biodefense viruses. Antiviral Chem. Chemother., 18, 301-305.
        • Selvam, P., Vijayalakshimi, P., Smee, D., Gowen, B., Julander, J., Day, C.W, Barnard, D., (2007). Novel 3-sulphonamido-quinazolin-4(3H)-one derivatives: microwave-assisted synthesis and evaluation of antiviral activities against respiratory and biodefense viruses.. Antiviral Chemistry and Chemotherapy/International Medical Press, 18:5, 301-5.
        • Smee, D., (2007). Identification of novel antipoxviral agents: mitoxantrone inhibits vaccinia virus replication by blocking virion assembly. J. Virol., 81, 13392-13402.
        • Smee, D., (2007). Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus. Antiviral Res., 76, 124-129.
        • Smee, D., (2007). Neutralizing viruses in suspensions by copper oxide based filters. Antimicrob. Agents Chemother., 51, 2605-2607.
        • Smee, D., (2007). Correlation between breakdown of the blood-brain barrier and disease outcome of viral encephalitis in mice. Antiviral Res., 75, 104-112.
        • Smee, D., (2007). Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc. Natl. Acad. Sci., 104, 3990-3995.
        • Smee, D., (2007). Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice. Antimicrob Agents Chemother., 51, 845-851.
        • Smee, D., (2007). Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice. Antiviral Res., 73, 69-77.
        • Smee, D., (2006). Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotype.. Antimicrob. Agents Chemother., 50, 4038-4043.
        • Smee, D., (2006). Anti-influenza virus activities of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N-(4,6-dimethyl-2-pyrimidin-2-yl)benzenesulphonamide and its derivatives.. Antiviral Chem. Chemother., 17, 269-274.
        • Smee, D., (2006). Activities of oseltamivir and ribavirin used alone and in combination against infections in mice with recent isolates of influenza A (H1N1) and B viruses.. Antiviral Chem. Chemother., 17, 185-192.
        • Smee, D., (2006). Combinatorial ribavirin and interferon alfacon-1 therapy of acute arenaviral disease in hamsters. Antimicrob. Agents Chemother., 50, 2023-2029.
        • Smee, D., (2006). Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infection.. Antiviral Res., 72, 125-133.
        • Smee, D., (2006). Recombinant Eimeria protozoan protein elicits resistance to acute phlebovirus infection in mice but not hamsters. Antimicrob. Agents Chemother., 50, 2023-2029.
        • Smee, D., (2006). Mutations in influenza virus M1 CCHH, the putative zinc finger motif, cause attenuation in mice and protect mice against lethal influenza infection.. J. Virol. 80:5697-5707., 80, 5697-5707.
        • Smee, D., (2006). Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection.. Antimicrob. Agents Chemother., 50, 1470-1479.
        • Smee, D., (2006). Protective immunity against acute phleboviral infection elicited through immunostimulatory cationic liposome-DNA complexes.. Antiviral Res., 69, 165-172.
        • Day, C.W, Smee, D., Julander, J., Yamshchikov, V.F, Sidwell, R.W, Morrey, J.D, (2005). Error-prone replication of West Nile virus caused by ribavirin.. Antiviral Res., 67:1, 38-45.
        • Smee, D., (2005). Broad-spectrum inhibitor of viruses in the Flaviviridae family.. Antiviral Res., 68, 49-55.
        • Smee, D., (2005). Characterization and treatment of cidofovir-resistant vaccinia (WR strain) virus infections in cell culture and in mice.. Antiviral Chem. Chemother., 16, 203-211.
        • Smee, D., (2005). Error-prone replication of West Nile virus caused by ribavirin.. Antiviral Res., 67, 38-45.
        • Smee, D., (2005). In vitro and in vivo influenza virus-inhibitory effects of viramidine.. Antiviral Res., 68, 17-Oct.
        • Smee, D., (2005). Interferon alfacon-1 protects hamsters from lethal Pichinde virus infection.. Antimicrob. Agents Chemother., 49, 2378-2386.
        • Smee, D., (2004). Anti-cowpox virus activities of certain adenosine analogs, arabinofuranosyl nucleosides, and 2'-fluoro-arabinofuranosyl nucleosides in cell culture and in mice.. Nucleosides Nucleotides Nucleic Acids, 25, 375-383.
        • Smee, D., (2004). Effect of interferon-alpha and interferon inducers on West Nile virus in mouse and hamster animal models.. Antiviral. Chem. Chemother., 15, 101-109.
        • Smee, D., (2004). Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice.. Int. J. Antimicrob. Agents, 23, 430-437.
        • Smee, D., (2004). Experimental disease models of influenza virus infections: recent developments.. Drug Disc. Today: Dis. Models, 1, 57-63.
        • Smee, D., (2004). In vitro activity of expanded spectrum pyridazinyl oxime ethers related to pirodavir: novel capsid-binding inhibitors with potent antipicornavirus activity.. Antimicrob. Agents Chemother., 48, 1766-1772.
        • Smee, D., (2004). Inhibition of severe acute respiratory syndrome-associated coronavirus (SARSCoV) by calpain inhibitors and �-D-N4-hydroxycytidine. Antiviral Chem. Chemother., 15, 15-22.
        • Smee, D., (2004). Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised mice.. J. Infect. Dis., 190, 1132-1139.
        • Smee, D., (2004). Treatment of mannan-enhanced influenza B virus infections in mice with oseltamivir, ribavirin and viramidine.. Antiviral Chem. Chemother., 15, 261-268.
        • Morrey, J.D, Day, C.W, Julander, J., Blatt, L.M, Smee, D., Sidwell, R.W, (2004). Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models.. Antivir Chem Chemother, 15:2, 101-109.
        • Smee, D., (2003). A review of compounds exhibiting antiorthopoxvirus activity in animal models.. Antiviral Res., 57, 41-52.
        • Smee, D., (2003). Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice.. Chemotherapy, 49, 126-131.
        • Smee, D., (2003). Inhibition of influenza virus infections in immunosuppressed mice with orally administered peramivir (BCX-1812).. Antiviral Res., 60, 17-25.
        • Sidwell, R.W, Bailey, K.W, Morrey, J.D, Wong, M.H, Baldwin, T.J, Smee, D., (2003). Inhibition of influenza virus infections in immunosuppressed mice with orally administered Peramivir (BCX-1812).. Antiviral Research, 60, 17-25.
        • Smee, D., (2003). The virucidal protein cyanovirin-N displays potent anti-influenza activity mediated through interactions with viral hemagglutinin.. Antimicrob. Agents Chemother., 47, 2518-2525.
        • Smee, D., (2003). Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control.. Antiviral Res., 57, 101-111.
        • Smee, D., (2002). Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia viruses.. Antimicrob. Agents Chemother., 46, 1326-1335.
        • Smee, D., (2002). Combination treatment of influenza A virus infections in cell culture and in mice with the cyclopentane neuraminidase inhibitor RWJ-270201 and ribavirin.. Chemotherapy, 48, 88-93.
        • Smee, D., (2002). Comparison of colorimetric, fluorometric, and visual methods for determining anti-influenza (H1N1 and H3N2) virus activities and toxicities of compounds.. J. Virol. Meth., 106, 71-79.
        • Smee, D., (2002). Coumarins and pyranocoumarins, potential novel pharmacophores for inhibition of measles virus replication.. Antiviral Chem. Chemother., 13, 39-59.
        • Smee, D., (2002). Identification of active antiviral compounds against a New York isolate of West Nile virus.. Antiviral Res., 55, 107-116.
        • Smee, D., (2002). Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza.. Expert. Opin. Investig. Drugs, 11, 859-869.
        • Smee, D., (2002). Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug.. Antiviral Res., 54, 113-120.
        • Smee, D., (2001). Antiviral activity and mode of action studies of ribavirin and mycophenolic acid against orthopoxviruses in vitro.. Antiviral Chem. Chemother., 12, 327-335.
        • Smee, D., (2001). Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201.. Antiviral Res., 52, 251-259.
        • Smee, D., (2001). Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activity.. Antimicrob. Agents Chemother., 45, 743-748.
        • Smee, D., (2001). Effects of cidofovir on the pathogenesis of a lethal vaccinia virus respiratory infection in mice.. Antiviral Res., 52, 55-62.
        • Smee, D., (2001). Influence of virus strain, challenge dose, and time of therapy initiation in the in vivo influenza inhibitory effects of RWJ-270201.. Antiviral Res., 51, 179-187.
        • Smee, D., (2001). Inhibition of measles virus replication by 5'-nor carbocyclic adenosine analogues.. Antiviral Chem. Chemother., 12, 241-250.
        • Smee, D., (2001). Intracellular phosphorylation of carbocyclic 3-deazaadenosine, an anti-Ebola virus agent.. Antiviral Chem. Chemother., 12, 251-258.
        • Smee, D., (2001). Pharmacodynamic evaluation of RWJ-270201, a novel neuraminidase inhibitor, in a lethal murine model of influenza predicts efficacy for once-daily dosing.. Antimicrob. Agents Chemother., 45, 2115-2118.
        • Smee, D., (2001). Primary immune system effects of the orally administered cyclopentane neuraminidase inhibitor RWJ-270201 in influenza virus-infected mice.. Intl. Immunopharmacol., 1, 1211-1218.
        • Smee, D., (2001). The in vivo influenza-inhibitory effects of the cyclopentane neuraminidase inhibitor RWJ-270201.. Antimicrob. Agents Chemother., 45, 749-757.
        • Smee, D., (2001). Treatment of lethal vaccinia virus respiratory infections in mice with cidofovir.. Antiviral Chem. Chemother., 12, 71-76.
        • Smee, D., (2001). Utilization of alpha-1-acid glycoprotein levels in the serum as a parameter for in vivo assay of influenza virus inhibitors.. Antiviral Chem. Chemother., 12, 359-365.
        • Smee, D., (2000). Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge.. J. Infect. Dis., 181, 19-Oct.
        • Smee, D., (2000). In vitro and in vivo systems for study of influenza virus inhibitors.. Antiviral Res., 48, 16-Jan.
        • Smee, D., (2000). Intranasal treatment of cowpox virus respiratory infections in mice with cidofovir.. Antiviral Res., 47, 171-177.
        • Smee, D., (2000). Spectrum of virus inhibition by consensus interferon YM643.. Antiviral Chem. Chemother., 11, 337-341.
        • Smee, D., (2000). Treatment of cowpox virus respiratory infections inmice with ribavirin as a single agent or followed sequentially by cidofovir.. Antiviral Chem. Chemother., 11, 303-309.
        • Smee, D., (1997). An immunosuppressed mouse model of lethal murine gammaherpesvirus-68 infection for studying potential treatments of Epstein-Barr virus infections in man.. Antiviral Chem. Chemother., 8, 573-581.
        • Smee, D., (1997). Metabolism of ganciclovir and cidofovir in cells infected with drug-resistant and wild-type strains of murine cytomegalovirus.. Antiviral Res., 35, 83-90.
        • Smee, D., (1996). Antiviral activities of tragacanthin polysaccharides on Punta Toro virus infections in mice.. Chemotherapy, 42, 286-293.
        • Smee, D., (1996). Combination of antiviral immunotoxin and ganciclovir or cidofovir for the treatment of murine cytomegalovirus infections.. Antiviral Res., 32, 165-171.
        • Smee, D., (1996). Potent anti-murine cytomegalovirus activity and reduced nephrotoxicity of ganciclovir cyclic phophonate.. Antimicrobial Agents Chemother., 40, 1964-1966.
        • Smee, D., (1996). Selective cytotoxicity of ricin A chain immunotoxins towards murine cytomegalovirus-infected cells.. Antimicrob. Agents Chemother., 40, 470-472.
        • Smee, D., (1995). Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus.. Antiviral Res. 26, 26, 9-Jan.
        • Smee, D., (1995). Antiviral activity of an immunomodulatory lipophilic desmuramyl MDP analogs.. Antiviral Research, 26, 145-159.
        • Smee, D., (1995). Broad-spectrum activity of 8-chloro-7-deazaguanosine against RNA virus infections in mice and rats.. Antiviral Res., 26, 203-209.
        • Smee, D., (1995). Effects of monoclonal antibody combined with ganciclovir or (S)-1-[3-hydroxy-(2-phosphonylmethoxy)propyl]cytosine against murine cytomegalovirus infections in cell culture and in severe combined immunodeficient mice.. Chemotherapy, 41, 141-148.
        • Smee, D., (1995). Effects of plant-derived polysaccharides on murine cytomegalovirus and encephalomyocarditis virus infections in mice.. Antiviral Chem. Chemother., 6, 385-390.
        • Smee, D., (1995). Selective cytotoxicity towards cytomegalovirus-infected cells by immunotoxins consisting of gelonin linked to anti-cytomegalovirus antibody.. Antiviral Res., 28, 93-100.
        • Smee, D., (1994). 1-[((S)-2-Hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo.. Antimicrob. Agents Chemother., 38, 2387-2391.
        • Smee, D., (1994). Antiviral and immunomodulating inhibitors of experimentally-induced Punta Toro virus infections.. Antiviral Res., 25, 105-122.
        • Smee, D., (1994). Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits the replication of human herpes viruses.. Antiviral Res., 23, 213-218.
        • Smee, D., (1994). In vitro and in vivo antiviral (RNA) evaluation of orotidine 5'-monophosphate decarboxylase inhibitors and analogues including 6-azauridine 5'-(ethylmethoxyalaninyl)phosphate (a 5'-monophosphate prodrug).. Antiviral Chem. Chemother., 5, 209-220.
        • Smee, D., (1994). Nucleotide analogs related to acyclovir and ganciclovir are effective against murine cytomegalovirus infections in BALB/c and severe combined immunodeficient mice.. Antimicrob. Agents Chemother., 38, 2165-2168.
        • Smee, D., (1994). SP-303, an antiviral oligomeric proanthocyanidin from the latex of Croton lechleri (Sangre de Drago).. Phytomedicine, 1, 77-106.
        • Smee, D., (1994). Vaccination against bovine herpes mammillitis virus infections in guinea pigs.. Intervirology, 37, 20-24.
        • Smee, D., (1993). Alkylpurines as immunopotentiating agents. Synthesis and antiviral activity of certain alkylguanines.. J. Med. Chem., 36, 3431-3436.
        • Smee, D., (1993). Anti-herpesvirus activity and mode of action of SP-303, a novel plant flavenoid.. Chemotherapy, 39, 203-211.
        • Smee, D., (1993). Murine cytomegalovirus-inhibitory effects of ImuVert.. Antiviral Res., 20, 279-292.
        • Smee, D., (1993). Treatment of lethal Pichinde virus infections in weanling LVG/Lak hamsters with ribavirin, ribamidine, selenazofurin, and ampligen.. Antiviral Res., 20, 57-70.
        • Smee, D., (1992). Antiviral and immunoenhancing properties of 7-thia-8-oxoguanosine and related guanosine analogues.. Can. J. Infect. Dis., 3(Suppl. B), 41B-48B.
        • Smee, D., (1992). Biological response modifiers in combination with antivirals against experimentally-induced virus infections.. Can. J. Infect. Dis., 3(Suppl. B), 49B-54B.
        • Smee, D., (1992). Ganciclovir treatment of murine cytomegalovirus infection in mice immunosuppressed by prior infection with Friend leukemia virus.. Antiviral Chem. Chemother., 3, 327-333.
        • Smee, D., (1992). Immunomodulatory activity of a novel nucleoside, 7-thia-8-oxoguanosine. 2. Characterization of induced effector cells and the mechanism of induction.. Immunopharmacol. Immunotoxicol., 14, 21-38.
        • Smee, D., (1992). Potential role of immunomodulators for treatment of Phlebovirus infections.. Ann. N.Y. Acad. Sci., 653, 344-355.
        • Smee, D., (1992). Selective inhibition of arthropod-borne and arenaviruses in vitro by 3'-fluoro-3'deoxyadenosine.. Antiviral Res., 18, 151-162.
        • Smee, D., (1992). Synthesis of certain aza and deazapurine nucleosides and their modulation of genetic expression.. Actual. Chim. Ther., 18, 183-191.
        • Smee, D., (1992). Treatment of murine cytomegalovirus infections in severe combined immunodeficient mice with ganciclovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)-propyl]cytosine, interferon and bropirimine.. Antimicrob. Agents Chemother., 36, 1837-1842.
        • Smee, D., (1992). Use of distance geometry approach for the in vitro antiviral activity evaluation of N-bridgehead C-nucleosides.. Eur. J. Med. Chem., 27, 259-266.
        • Smee, D., (1991). Combination chemotherapy of Punta Toro virus infections in mice using ribavirin and 7-thia-8-oxoguanosine.. Antiviral Chem. Chemother., 2, 93-97.
        • Smee, D., (1991). Immunoenhancing properties and antiviral activity of 7-deazaguanosine in mice.. Antimicrob. Agents Chemother., 35, 152-157.
        • Smee, D., (1991). In vivo antiviral activity of 5-amino-1-methyl-3-�-D-ribofuranosyl-pyrazolo[4,3-d]pyrimidin-7(6H)-one and related guanosine analogues prepared from formycin.. Nucleosides Nucleotides, 10, 1417-1427.
        • Smee, D., (1991). Progressive murine cytomegalovirus disease after termination of ganciclovir therapy in mice immunosuppressed by cyclophosphamide treatment.. J. Infect. Dis., 164, 958-961.
        • Smee, D., (1991). Prophylactic and therapeutic activities of 7-thia-8-oxoguanosine against Punta Toro virus infections in mice.. Antiviral Res., 15, 229-239.
        • Smee, D., (1991). Synthesis and antiviral activity of certain guanosine analogues in the thiazolo-[4,5-d]pyrimidine ring system.. J. Med. Chem., 34, 3006-3010.
        • Smee, D., (1990). 4,6-Dibenzamidopyrazolo[3,4-d]pyrimidine is a highly selective inhibitor of cytomegalovirus adsorption to cells.. Antiviral Res., 13, 10-Jan.
        • Smee, D., (1990). Antiviral activity of the novel immune modulator 7-thia-8-oxoguanosine.. J. Biol. Response Mod., 9, 24-32.
        • Smee, D., (1990). Direct C-glycosylation of guanine analogues: The synthesis and antiviral activity of certain 7-and 9-deazaguanine C-nucleosides.. J. Med. Chem., 33, 2174-2178.
        • Smee, D., (1990). Guanosine analogues. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo[3,4-d]pyrimidin-4(5H)-ones as potential immunotherapeutic agents.. J. Med. Chem., 33, 2174-2178.
        • Smee, D., (1990). Inhibition of Phlebovirus infections in vivo by tiazofurin and selenzaofurin.. Antiviral Chem. Chemother., 1, 211-216.
        • Smee, D., (1990). Intranasal treatment of picornavirus and coronavirus respiratory infections in rodents using 7-thia-8-oxoguanosine.. Antiviral Chem. Chemother., 1, 47-52.
        • Smee, D., (1990). Roles of interferon and natural killer cells in the antiviral activity of 7-thia-8-oxoguanosine against Semliki Forest virus infections in mice.. Antiviral Res., 13, 91-102.
        • Smee, D., (1990). Synthesis and antiviral activity of the 3-deaza analogue of 9-[1,3-dihydroxy-2-propoxy)methyl]guanine.. Nucleosides Nucleotides, 9, 815-826.
        • Smee, D., (1990). Synthesis and broad-spectrum antiviral activity of 7,8-dihydro-7-methyl-8-thioxoguanosine.. J. Med. Chem., 33, 2127-2130.
        • Smee, D., (1990). Synthesis and in vivo antitumor and antiviral activities of 2'-deoxyribofuranosyl and arabinofuranosyl nucleosides of certain purine-6-sulfenamides, sulfinamides and sulfonamides.. J. Heterocycl. Chem., 27, 909-918.
        • Smee, D., (1990). Thiazolo[4,5-d]pyrimidine nucleosides. The synthesis of certain 3-�-D-ribofuranosylthiazolo[4,5-d]pyrimidines as potential immunotherapeutic agents.. J. Med. Chem., 33, 407-415.
        • Smee, D., (1989). Analysis of the in vitro antiviral activity of certain ribonucleosides against parainfluenza virus using a novel computer aided receptor modeling procedure.. J. Med. Chem., 32, 746-756.
        • Smee, D., (1989). Antitumor and antiviral activity of synthetic a- and �-ribonucleosides of certain substituted pyrimido[5,4-d]pyrimidines: a new synthetic strategy for exocyclic aminonucleosides.. J. Med. Chem., 32, 629-637.
        • Smee, D., (1989). Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent.. Antimicrob. Agents Chemother., 33, 1487-1492.
        • Smee, D., (1989). Evaluation of continuous cell lines in antiviral studies with murine cytomegalovirus.. Arch. Virol., 107, 253-260.
        • Smee, D., (1989). Nucleoside and nucleotide modulation of genetic expression - a new approach to chemotherapy.. Adv. Enzyme Regul., 29, 97-121.
        • Smee, D., (1989). Synthesis and biological properties of purine and pyrimidine 5'-deoxy-5'-(dihydroxyphosphinyl)-�-D-ribofuranosyl analogues of AMP, GMP, IMP and CMP.. J. Med. Chem., 32, 1307-1313.
        • Smee, D., (1989). Synthesis of tubercidin, 6-chlorotubercidin and related nucleosides.. Nucleosides Nucleotides, 8, 1201-1216.
        • Smee, D., (1988). Antiviral activities of 2'-deoxyribofuranosyl and arabinofuranosyl analogs of sangivamycin against retro- and DNA viruses.. Antiviral Res., 10, 263-278.
        • Smee, D., (1988). Antiviral activity and mode of action of ribavirin 5'-sulfamate against Semliki Forest virus.. Antiviral Res., 10, 253-262.
        • Smee, D., (1988). Inhibition of orotidylate decarboxylate by 4(5H)-oxo-1-�-D-ribofuranosylpyrazolo-3,4-d]pyrimidine-3-thiocarboxamide (APR-TC) in B lymphoblasts.. Biochem. Pharmacol., 37, 4697-4705.
        • Smee, D., (1988). Synthesis and anti-herpetic activity of 2'-fluorarabinosyl analog of trifluridine.. Nucleosides Nucleotides, 7, 155-165.
        • Smee, D., (1987). Novel pyrazolo[3,4-d]pyrimidine nucleoside analog with broad-spectrum antiviral activity.. Antimicrob. Agents Chemother., 31, 1535-1541.
        • Smee, D., (1987). Visna virus as an in vitro model for human immunodeficiency virus and inhibition by ribavirin, phosphonoformate, and 2',3'-dideoxynucleosides.. Antimicrob. Agents Chemother., 31, 1369-1374.
        • Smee, D., (1986). In vitro and in vivo activities of phosphate derivatives of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine against cytomegaloviruses.. Antiviral Res., 6, 299-308.
        • Smee, D., (1986). Metabolism of ribavirin in respiratory syncytial virus-infected and uninfected cells.. Antimicrob. Agents Chemother., 30, 117-121.
        • Smee, D., (1986). Synthesis and anti-herpes virus activity of phosphate and phosphonate derivatives of 9-[1,3-dihydroxy-2-propoxy)methyl]guanine.. J. Med. Chem., 29, 671-675.
        • Smee, D., (1986). Synthesis and anti-herpesvirus activity of acyclic 2'-deoxyguanosine analogues related to 9-[1,3-dihydroxy-2-propoxy)methyl]guanine.. J. Med. Chem., 29, 1384-1389.
        • Smee, D., (1985). Activities of arabinosyladenine monophosphate and 9-(1,3-dihydroxy-2-propoxy-methyl)guanine against ground squirrel hepatitis virus in vivo as determined by reduction in serum virion-associated DNA polymerase.. Antimicrob. Agents Chemother., 27, 277-279.
        • Smee, D., (1985). Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compred with that of acyclovir against human,monkey and rodent cytomegaloviruses.. Antimicrob. Agents Chemother., 28, 240-245.
        • Smee, D., (1985). Acyclic analogues of 2'-deoxynucleosides related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine as potential antiviral agents.. J. Med. Chem., 28, 358-362.
        • Smee, D., (1985). Comparative anti-herpesvirus activities of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, acyclovir, and two 2'-fluoropyrimidine nucleosides.. Antiviral Res., 5, 259-267.
        • Smee, D., (1985). Interaction of 9-(1,3-dihydroxy-2-propoxymethyl)guanine with cytosol and mitochondrial deoxyguanosine kinases: possible role in anticytomegalovirus activity.. Mol. Cell. Biochem., 69, 75-81.
        • Smee, D., (1985). Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and acyclovir in herpes simplex virus-infected and uninfected cells.. Biochem. Pharmacol., 34, 1049-1056.
        • Smee, D., (1985). Synthesis and antiherpes simplex virus activity of 9-[(1,3-dihydroxy-2-propylthio)methyl]guanine.. J. Med. Chem., 28, 1242-1245.
        • Smee, D., (1985). Synthesis of 9-(4-hydroxy-2-oxobutyl)guanine, 9-(2,4-dihydroxybutyl)guanine and related nucleoside analogues.. J. Org. Chem., 50, 755-559.
        • Smee, D., (1984). Synthesis and antiherpes simplex virus activity of 9-[4-hydroxy-3[(hydroxymethyl)-1-butyl]guanine.. Nucleosides Nucleotides, 3, 525-535.
        • Smee, D., (1983). Efficacy of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine against primary and recrudescent genital herpes simplex virus type 2 infections in guinea pigs.. Antimicrob. Agents Chemother., 24, 883-887.
        • Smee, D., (1983). Lack of efficacy of AMP against recrudescent genital herpes infections in guinea pigs.. Antimicrob. Agents Chemother., 24, 611-612.
        • Smee, D., (1983). Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine.. Antimicrob. Agents Chemother., 23, 676-682.
        • Smee, D., (1983). 9-[1,3-Dihydroxy-2-propoxy)methyl]guanine: a new potent and selective antiherpes agent.. J. Med. Chem., 26, 759-761.
        • Smee, D., (1982). Inhibition of rotaviruses by selected antiviral substances: mechanisms of viral inhibition and in vivo studies.. Antimicrob. Agents Chemother., 21, 66-73.
        • Smee, D., (1981). Inhibition of reoviruses by selected antiviral substances.. Antiviral Res., 1, 315-323.
        • Smee, D., (1981). Inhibition of bluetongue and Colorado tick fever orbiviruses by selected antiviral substances.. Antimicrob. Agents Chemother., 20, 533-538.
        • Smee, D., (1981). Bovine leukemia virus inhibition in vitro by ribavirin.. Antiviral Research, 1, 47-53.
        • Smee, D., (1981). Development of antiviral levels of ribavirin in serum and urine from orally treated rats.. Chemotherapy, 27, 17-Dec.
        • Smee, D., (1981). Bioassay system for determining ribavirin levels in human serum and urine.. Chemotherapy, 27, 11-Jan.
        • Professional Journal

        • Gowen, B., Sefing, E.J, Westover, J.B, Smee, D., Hagloch, J.H, Furuta, Y., Hall, J.O, (2015). Alterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever. Antiviral Res , 121, 132–137.
        • Julander, J., Bantia, S., Taubenheim, B.R, Minning, D.M, Kotian, P., Morrey, J.D, Smee, D., Sheridan, W.P, Babu, Y.S, (2014). BCX4430, a novel nucleoside analog, effectively treats yellow fever in a hamster model. Antimicrobial Agents and Chemotherapy, 58:11, 6607-6614.

        * Has not been peer reviewed

        Publications - Literary Journal

          * Has not been peer reviewed

          Publications - MultiMedia

            * Has not been peer reviewed

            Publications - Technical Reports

              Research Reports

            • Smee, D., Barnard, D., Jones, S.M, (2016). Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice. Antiviral Research
            • Warfield, K.L, Barnard, D., Enterlein, S.G, Smee, D., Khaliq, M., Sampath, A., Callahan, M.V, Ramstedt, U., Day, C.W, (2016). The iminosugar UV-4 is a broad inhibitor of influenza A and B viruses ex vivo and in mice. Viruses
            • Koday, M.T, Nelson, J., Chevalier, A., Koday, M., Kalinoski, H., Stewart, L., Carter, L., Neiusma, T., Lee, P.S, Ward, A.B, Wilson, I.A, Dagley, A., Smee, D., Baker, D., Fuller, D.H, (2016). A Computationally Designed Hemagglutinin Stem-binding Protein Provides in vivo Protection from Influenza Independent of a Host Immune Response. PLoS Pathogens
            • Smee, D., Wong, M., Russell, A., Ennis, J., Turner, J.D, (2011). Therapy and long-term prophylaxis of vaccinia virus respiratory infections in mice with an adenovirus-vectored interferon alpha (mDEF201). PLoS ONE
            • Morrey, J.D, Barnard, D., Smee, D., Gowen, B., (2009). Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Smee, D., Barnard, D., Morrey, J.D, Gowen, B., Julander, J., (2009). Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Morrey, J.D, Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2009). Semi-Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Smee, D., Barnard, D., Morrey, J.D, Gowen, B., Julander, J., (2009). Semi-Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Morrey, J.D, Barnard, D., Smee, D., Gowen, B., (2008). Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Morrey, J.D, Barnard, D., Smee, D., Gowen, B., (2008). Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Smee, D., Barnard, D., Morrey, J.D, Gowen, B., Julander, J., (2008). Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Morrey, J.D, Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2008). Semi-Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Smee, D., Barnard, D., Morrey, J.D, Gowen, B., Julander, J., (2008). Semi-Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Morrey, J.D, Barnard, D., Smee, D., Gowen, B., (2007). Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Smee, D., Barnard, D., Morrey, J.D, Gowen, B., Julander, J., (2007). Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Morrey, J.D, Barnard, D., Smee, D., Gowen, B., (2007). Semi-Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Smee, D., Barnard, D., Morrey, J.D, Gowen, B., Julander, J., (2007). Semi-Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2006). Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., Julander, J., (2006). Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., Julander, J., (2006). Semi Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2006). Semi-Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2005). Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2005). Semi Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2005). Semi-Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2004). Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2004). Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2004). Semi Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2004). Semi-Annual Report NO1-AI-15435, NIAID, NIH. Animals Models of Human Experimental Viral Infections for Evaluation of Experimental Therapies.
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2003). Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2003). Semi Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2002). Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2002). Semi Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2001). Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2001). Semi Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2000). Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (2000). Semi Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (1999). Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .
            • Sidwell, R., Barnard, D., Morrey, J.D, Smee, D., Gowen, B., (1999). Semi Annual Report NO1-AI-85348, NIAID, NIH. In vitro antiviral screen for respiratory viruses. .

            * Has not been peer reviewed

            Publications - Translations & Transcripts

              Publications - Other

                Other

              • Smee, D., (1994). Inhibitors of bovine herpes mammillitis virus infections in cultured cells and in vaginally-infected guinea pigs.. Antiviral Chem. Chemother. *

              * Has not been peer reviewed