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Biotechnology, Epigenetics, and Stem Cell Research

Research in the Biotechnology, Epigenetics, and Stem Cell Research area is diverse and includes:

  • Studying embryonic stem (ES) cells and induced pluripotent stem (iPS) cells in laboratory animals (golden Syrian hamster, guinea pig, and naked mole-rat, etc.) and farm animals (cattle, goat, sheep, and pig, etc.)
  • Animal cloning by somatic cell nuclear transfer (SCNT) in the above-mentioned species, and studying the epigenetics of genomic reprogramming and its impacts on embryogenesis and fetal development
  • Developing genetically engineered non-murine animal models of human diseases
  • Using mice as animal models to study how nutritional and environmental exposures during prenatal development change the germline epigenome.
  • Mechanisms of sperm epigenetic programming and its impact on offspring health; heritable diseases of epigenetic origin (transgenic mouse models)
  • Establishing heterochronic gonadal somatic cell isolation and in vivo transplantation procedures in rodents
  • Investigations on environmental impacts on the epigenome in the context of cancer development