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Restoration of immune and renal function in aged females by re-establishment of active ovarian function

Restoration of immune and renal function in aged females by re-establishment of active ovarian function

Proper immune functioning is necessary to maximize reproductive success. In addition, age-associated uremia in women is often associated with hypothalamic–pituitary–gonadal dysfunction.

Transplantation of young ovaries restored cardioprotective influence in postreproductive-aged mice.

Transplantation of young ovaries restored cardioprotective influence in postreproductive-aged mice.

The female cardioprotective advantage, present in mammals of a reproductively competent age, is lost during the transition to a postreproductive state.

Restoration of immune and renal function in aged females by re-establishment of active ovarian function

Restoration of immune and renal function in aged females by re-establishment of active ovarian function

In the degenerative environment of osteoarthritis (OA), the enzymes responsible for the degradation of aggrecan, a major proteoglycan of cartilage are up-regulated.

The Influence of Oblique Angle Forced Exercise in Surgically Destabilized Stifle Joints Is Synergistic with Bone but Antagonistic with Cartilage in an Ovine Model of Osteoarthritis

The Influence of Oblique Angle Forced Exercise in Surgically Destabilized Stifle Joints Is Synergistic with Bone but Antagonistic with Cartilage in an Ovine Model of Osteoarthritis

Large animal models of osteoarthritis are a necessary testing ground for FDA approval of human medicine applications. Sheep models have advantages over other available large animals, but development and progression of osteoarthritis in sheep is exceedingl...

TNF [alpha] promotes proliferation of oligodendrocyte progenitors and remyelination

TNF [alpha] promotes proliferation of oligodendrocyte progenitors and remyelination

Here we used mice lacking tumor necrosis factor-alpha (TNF alpha) and its associated receptors to study a model of demyelination and remyelination in which these events could be carefully controlled using a toxin, cuprizone.

Delivery and evaluation of recombinant adeno-associated viral vectors in the equine distal extremity for the treatment of laminitis

Delivery and evaluation of recombinant adeno-associated viral vectors in the equine distal extremity for the treatment of laminitis

Vector serotypes rAAV2/1, 2/8 and 2/9 all successfully transduced equine foot tissues and displayed similar levels and patterns of transduction. The regional distribution of transduction within the foot decreased with decreasing vector dose.

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