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Young-Min Lee

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ADVS

Molecular Virology, Viral Replication and Pathogenesis

Associate Professor

Educational Background

PhD, Molecular Virology, (Molecular Microbiology and Immunology), Johns Hopkins University, 1998
Role of the human immunodeficiency virus type 1 matrix (MAp17) protein in viral morphogenesis in infected CD4+ T cells
BS, Biological Science, University of Minnesota, 1993
N/A
BS, Biology, Chung-Ang University, 1991
N/A


Biography

I received my first B.S. degree in Biology from Chung-Ang University (Seoul, Korea) in 1991 and my second B.S. degree in Biological Sciences from the University of Minnesota (St. Paul, MN) in 1993. I then completed my Ph.D. training in 1998 at Johns Hopkins University (Baltimore, MD). I did ~2 years of post-doctoral research at Washington University (St. Louis, MO). From 2000 to 2011, I was a faculty member of the Chungbuk National University (Cheongju, Korea) Medical School and achieved the rank of full professor in 2011. In 2012, I joined the Utah State University as an Associate Professor of the Animal, Dairy and Veterinary Sciences department. I am currently directing a molecular virology laboratory, with a major focus on the molecular mechanisms of replication and pathogenesis of three clinically important human/animal pathogens (Zika virus, Japanese encephalitis virus, and porcine reproductive and respiratory syndrome virus).

Teaching Interests

Not Applicable.

Research Interests

As a molecular virologist, the research in my laboratory focuses on elucidating the molecular mechanisms of viral replication and pathogenesis, a crucial step toward developing new antiviral therapeutic and preventive strategies against three plus-strand RNA viruses that are important for human/animal health: Zika virus (ZIKV), Japanese encephalitis virus (JEV), and porcine reproductive and respiratory syndrome virus (PRRSV). Although the three viruses are clinically important, the basis of their replication and pathogenesis remains largely unknown, mainly because these viruses contain a genome consisting of a single-strand, positive-sense RNA molecule that cannot be manipulated directly in vitro for functional studies of viral RNA sequences and gene products. During the past ~15 years, the research in my laboratory has made several major contributions to this field: One of the most significant accomplishments is the construction of full-length infectious cDNA molecular clones for each of these three RNA viruses that serve as a template for the genetic manipulation of the viral genome, allowing the production of molecularly defined mutant viruses for biological studies. By using our new infectious cDNA technology, combined with innovative molecular biology, cell biology, and biochemical techniques, our research will answer key questions about the viral life cycle and cellular and host responses to viral infections, enabling us to discover a novel target(s) for the development of antiviral therapeutics and vaccines against ZIKV, JEV, and PRRSV, as well as closely related other pathogens.


Contact Information

Go toOffice Location: USTAR Bioinnovations 205L
DialPhone: 435-797-9667
SendEmail: youngmin.lee@usu.edu

Awards

Gaeshin Academic Award, 2011

Chungbuk National University

Best Paper Award in Science and Technology, 2009

Korean Federation of Science and Technology Societies

Faculty Excellence Award, 2005

Chungbuk National University

Excellence in Scientific Research Award, 2004

Ministry of Health and Welfare (Korea)

Katharine E. Welsh Fellowship, 1995

Johns Hopkins University

    Publications - Books & Book Chapters

      Book Chapters

    • Yun, S., Lee, Y., (2015). Japanese encephalitis: Antimicrobial Therapy and Vaccines (3rd ed). Antimicrobe.org
    • Lee, Y., (2013). Chapter 04: Diagnosis and Research Methods: Virology. Life Science
    • Lee, Y., (2013). Chapter 12: Flaviviruses: Virology. Life Science
    • Lee, Y., (2013). Chapter 17: Retroviruses: Virology. Life Science
    • Lee, Y., (2013). Chapter 22: HIV and AIDS : Virology. Life Science
    • Lee, Y., (2013). Chapter 04: Structure : Principles of Virology. World Science
    • Lee, Y., (2013). Chapter 06: Synthesis of RNA from RNA templates : Principles of Virology. World Science
    • Lee, Y., (2010). Chapter 04: Diagnosis and research methods: Virology. Life Science
    • Lee, Y., (2010). Chapter 12: Flavivirues: Virology. Life Science
    • Lee, Y., (2010). Chapter 18: Retroviruses: Virology. Life Science
    • Lee, Y., (2010). Chapter 24: Viral pathogenesis: Virology. Life Science
    • Lee, Y., (2010). Chapter 25: HIV and AIDS: Virology. Life Science
    • Lee, Y., (2009). Chapter 59: Flaviviridae: Medical Microbiology, 6e. Elsevier Korea
    • Lee, Y., (2008). Chapter 24: Enveloped RNA viruses: Nursing Microbiology, 1e. Elsevier Korea
    • Lee, Y., (2007). Chapter 61: Flaviviridae: Medical Microbiology, 5e. Elsevier Korea
    • Lee, Y., (2006). Chapter 11: Transformation: Fundamental Bacterial Genetics. World Science
    • Lee, Y., (2006). Chapter 12: Gene expression and regulation: Fundamental Bacterial Genetics. World Science
    • Yun, S., Lee, Y., (2006). Japanese encephalitis virus: Molecular biology and vaccine development: Molecular Biology of the Flavivirus. Horizon Bioscience (Horizon Scientific Press) *
    • Lee, Y., (2005). Chapter 64: Flaviviridae: Medical Microbiology, 4e. Elsevier Singapore

    * Has not been peer reviewed

    Publications - Fact Sheets

      * Has not been peer reviewed

      Publications - Curriculum

        * Has not been peer reviewed

        Publications - Journal Articles

        * Has not been peer reviewed

        Publications - Literary Journal

          * Has not been peer reviewed

          Publications - MultiMedia

            * Has not been peer reviewed

            Publications - Technical Reports

              * Has not been peer reviewed

              Publications - Translations & Transcripts

                Publications - Other

                  * Has not been peer reviewed

                  Graduate Students Mentored

                  Jordan Frank, Animal, Dairy and Veterinary Sciences, September 2016
                  Michael Woolley, Animal, Dairy and Veterinary Sciences, September 2016