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Lee Rickords

Lee Rickords

Associate Professor
Faculty: DVM, Faculty, Research
Location:  AGRS 241
Office Phone:  435-797-2195
Fax:  435-797-2118
Utah State University
4815 Old Main Hill
Logan, UT 84322-4815

Specialties: Molecular genetics, developmental biology

 

Academic Information


For Students

  • Classes I Teach
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    • ADVS 4260 Internship in Animal Biotechnology Industry:  Directed and evaluated educational work experience with an animal biotechnology unit, or with a related business or government facility.  Prerequisites:  ADVS 5160 or ADVS 5260 or permission of instructor, Fall, Spring and Summer Semester, 2-12 credits
    • ADVS 4560 Principles of Animal Genetics and Breeding:  Genetic influences affecting animal performance and the application of selection principles, breeding systems, and methods of improvement to farm animals, including beef and dairy cattle, sheep, swine, and horses. Fall Semester, 3 credits
    • ADVS 5260/6260 Methods in Biotechnology: Molecular Cloning:  Laboratory-oriented course designed to teach molecular biology techniques such as DNA cloning, genetic probes, polymerase chain reaction, and DNA sequencing.  Prerequisites:  Chem 3700 or Chem 5710 or Biol 3060 or permission of instructor.  Fall Semester.
      ADVS 5280 Animal Molecular Biology:  A laboratory-based course designed to present the theory and provide in-depth laboratory experience in RNA detection, differential gene expression analysis, real-time reverse transcription polymerase reaction (qRT-PCR), protein detection and purification, 2-D gel electrophoesis and microarrays.  Prerequisite:  ADVS 5260 or permission of Instructor.  Spring Semester, 3 credits.
    • ADVS 6210/7210 Molecular Reproduction and Development:  Lecture-based course focusing on current knowledge of genes associated with gametogenesis, fertilization, nuclear reprogramming, and embryonic and fetal development.  Prerequisite:  ADVS 6200 or permission of instructor.  Spring Semester, 3 credits.
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Education and Research

  • Education
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    • Ph.D. - Louisiana State University, Baton Rouge, LA, 1991
      • Major:  Animal Science (Reproductive Physiology)
      • Minor:  Zoology (Molecular Biology)
    • M.S. - Brigham Young University, Provo, UT, 1990
      • Animal Science (Reproductive Physiology)
    • B.S. - Animal Science, Brigham Young University, Provo, UT, 1984
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  • Professional Experience
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    • Associate Professor, Animal, Dairy and Veterinary Sciences, (Molecular Embryology/Genetics) Utah State University, Logan, UT, January 1, 2004-present.
      • Teaching Responsibilities: 
        • Animal Molecular Biology (5280/6280)
        • Molecular Reproduction and Development (6210/7210)
    • Adjunct Associate Professor, Biochemistry, Oklahoma State University Center for Health Sciences, February 1, 2004-present.
    • Member of the Graduate Faculty, Oklahoma State University, Sillwater, OK, May, 1995-present.
    • Associate Professor, Biochemistry (Molecular Genetics), Oklahoma State University Center for Health Sciences, July 1, 2002-February 1, 2004.  Tenure awarded July 1, 2002.
      • Teaching Responsibilities:
        • Medical Biochemistry - nucleic acids/molecular genetics
        • Techniques in Molecular Biology (graduate course)
        • Medical Genetics (graduate course - molecular genetics emphasis)
        • Embryology (graduate course - pre- and per-implantation section)
        • Molecular and Cellular Biology (replication, transcription, translation)
      • Research Interests:
        • Nuclear programming of stem cells and adult somatic cells
        • Gene regulation and protein transduction in early embryonic and mammalian stem cells
        • Gene screening and gene targeting
    • Assistant Professor, Biochemistry (Molecular Genetics), Oklahoma State University Center for Health Sciences, October 1, 1997-June 30, 2002.
    • Director of Molecular Preimplantation Genetics, H.A. Chapman Research Institute of Medical Genetics, Children's Medical Center, Tulsa, OK, October 5, 1992-September, 1997.
      • Responsible for developing and implementing testing procedures and performing research leading to the diagnosis of genetic diseases in genomic DNA and preimplantation stage embryos.
      • Objectives included the diagnosis, analysis and sequencing of genes in the study of genetic diseases and early developmental anomalies.  Research also involved studying gene regulation of nuclear transferred nuclei and developing/modifying fluorescence in situ hybridization (FISH) procedures for single-cell analysis.
    • Postdoctoral Fellow, Department of Animal Sciences (Molecular and Reproductive Cell Biology), University of Missouri-Columbia, January 1, 1991-September 30, 1992.
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  • Teaching Experience
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    • Spring Semesters, 2005-present - Animal Molecular Biology (5280/6280), Animal, Dairy and Veterinary Sciences Department, Utah State University, Logan, UT.
    • March 14-17, 2006 - "Stem cell research and applications in human regenerative medicine and agriculture" with hands-on laboratory.  Short course in: "Techniques in animal cell culture and scale-up strategies".  Center for Integrated Biosystems, Utah State University.
    • Fall Semester, 2006 - Special Topics course - regarding US-AID grant submission.
    • Taught hands-on laboratory on "Mammalian Cloning via Nuclear Transplantation" at OSU-Stillwater, May 1, 2002.
    • October 4-27, 1999 - Invited to the Royal Veterinary and Agricultural University, Copenhagen, Denmark to train colleagues and perform collaborative research in genetic anomalies of IVF and cloned bovine embryos.
    • Spring Semester, 1998 - Team/taught the Medical Information Sciences course at the College of Osteopathic Medicine, Oklahoma State University.
    • Fall Semester, 1997 to 2003 - Teaching Responsibilities: 
      • Medical Biochemistry - nucleic acids/molecular genetics section
      • Medical Molecular Genetics
      • Techniques in Molecular Biology
      • Embryology
      • Cellular and Molecular Biology at Oklahoma State University Center for Health Science, Tulsa, OK
    • Fall Semester, 1996 - Team/taught the molecular portion of the Medical Biochemistry course for the Department of Biochemistry at the College of Osteopathic Medicine, Oklahoma State University.
    • October 5, 1992 to September, 1997 - Routinely trained graduate/undergraduate students, visiting scientists, medical students and residents in molecular genetics, molecular biology techniques, preimplantation genetic diagnosis and nuclear transplantation.  In addition, selected undergraduates are involved in a summer intern program and are trained in advanced aspects of molecular biology and genetics.
    • August 25 to September 13, 1996 - Invited to the Royal Veterinary and Agricultural University, Copenhagen, Denmark to train scientists in single-cell fluorescence in-situ hybridization and genetic analysis.
    • April 24 to May 14, 1992 - Trained Hungarian scientists at the National Agricultural Biotechnology Center, Godollo, Hungry, in nuclear transplantation and molecular analysis of mammalian embryos.
    • Spring 1988, Spring 1989 - Laboratory instructor for graduate course "Gamete and Embryo Physiology and Micromanipulation".  Topics included cloning mammalian embryos by nuclear transplantation, production of transgenic animals, production of monozygotic twins and chimeras, microinjection of sperm into mammalian oocytes, in vitro maturation and in vitro fertilization culture of embryos and cryopreservation of embryos and tissue culture cells.
    • Fall 1987 - Instructor for Louisiana State University Short Course:  "Techniques in Embryo Transfer".  Taught all aspects of superovulation, collection, transfer and cryopreservation of embryos.
    • Spring 1985, Fall 1985, Winter 1986 - Laboratory instructor for undergraduate course:  "Anatomy and Physiology".  Responsibilities included teaching and assisting in the development of the laboratory curriculum.
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  • Training and Research Experience
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    • Associate Professor - Animal, Dairy and Veterinary Sciences Department, Utah State University, Logan, UT, 2004-present.
    • Associate Professor - Biochemistry, Oklahoma State University Center for Health Sciences, Tulsa, OK, 2002-2004.
    • Assistant Professor - Biochemistry, Oklahoma State University Center for Health Sciences, Tulsa, OK, 1997-2001.
    • Director - Preimplantation Genetics, H.A. Chapman Research Institute of Medical Genetics, Tulsa, OK, 1992-1997.
    • Course in Medical and Experimental Mammalian Genetics - The Jackson Laboratory, Bar Harbor, ME, July 17-28, 1995.
    • International Symposium on Preimplantation Genetic Analysis of Mammalian Embryos - New York, NY, June 3-5, 1994.
    • Postdoctoral Fellow - Department of Animal Sciences (Molecular and Reproductive Cell Biology), University of Missouri-Columbia, 1991-1992.
    • Graduate Research Assistant - Department of Animal Science (Molecular and Reproductive Cell Biology), Louisiana State University, 1986 to 1990.
    • Graduate Research Assistant - Department of Animal Science, Brigham Young University, Provo, UT, 1985-1986.
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  • Publications
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    I have over 29 publications. The following are the latest 10.
    1. Aston K.I., G.P. Li, B.A. Hicks, B.R. Sessions, A.P. Davis, L.F. Rickords, J.R. Stevens, K.L. White.  (2010)  Abnormal levels of transcript abundance of developmentally important genes in various stages of preimplantation bovine somatic cell nuclear transfer embryos.  Cell Reprogram 12:23-32.
    2. Aston K.I., G.P. Li, B.A. Hicks, B.R. Sessions, A.P. Davis, Q.A. Winger, L.F. Rickords, J.R. Stevens, KL. White.  (2009) Global gene expression analysis of bovine somatic cell nuclear transfer blastocyst and cotyledons.  Mol Reprod Dev 76:471-82.
    3. Morrill, B.H., L.F. Rickords, H.J. Schafstall.  (2009) Sequence length polymorphisms wihin cervid amelogenin-X and amelogenin-Y genes.  Use in sex determination.  Wild Biol Pract 5(2):89-95.
    4. Morrill, B.H., L.F. Rickords, H.J. Schafstall.  (2008) Sequence length polymorphisms within primate emelogenin and amelogenin-like genes:  Usefulness in sex determination.  Am J Primatology 70:976-985.
    5. Elliott, K.A., L.F. Rickords, J.M. Young.  (2008)  Transduction of E2F-1 Fat Fusion Proteins Represses Expression of HTERT in Primary Ductal Breast Carcinoma Cell Lines.  Molecular Cancr 7:28-38.
    6. Liu, Y., G.P. Li, B.R. Sessions, K.L. White, L. Rickords, K.I. Aston, and T.D.  Bunch.  (2008)  Nicotine Induces Multinuclear Formation and Causes Aberrant Embryonic Development in Bovine.  Mol Reprod Dev 75:801-809.
    7. Liu, Y., G-P, Li, L.F. Rickords, K.L. White, B.R. Sessions, Kenneth I. Aston and Thomas D. Bunch.  (2008)  Nicotine Induced Diploidy in In Vitro Matured Bovine Oocytes.  Anim Reprod Sci 103:13-34.
    8. Liu, Y., G-P. Li, K.L. White, L.F. Rickords, B.J. Sessions, K.L. Aston, and T.D. Bunch.  (2007)  Nicotine Alters Bovine Oocyte Meiosis and Affects Subsequent Embryonic Development. Mol Reprod Dev. 74:1473-1482.
    9. Pate, B.J., K.L. White, Q.A. Winger, L.F. Rickords, K.I. Aston, B.R. Sessions, G.P. Li, K.D. Campbell, B. Weimer and T.D. Bunch. (2007)  Specific Intergrin Subunits in Bovine Oocytes including Novel Sequences for Alpha 6 and Beta 3 Subunits. Mol Reprod Dev 74:600-607.
    10. Bolette, B., D. Viuff, H. Pedersen, L. Rickords, L. Lai,H. Cheong, M. Samuel, R. Prather, . Stgrejcek, Z. Rasmussen, J. Laurincik, C. Rosenkranz, H.Niemann, P. Hyttel, P. Thomsen.  2007.  Activation of ribosomal RNA genes in porcine embryos produced in vitro or by somatic cell nuclear transfer.  Mol Reprod Dev 74:35-41.
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Honors and Activities

  • Committees
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    • Executive Committee
    • Faculty Search and Screening Committee Chair
    • Graduate Program Committee
    • Internship and Placement Committee
    • Prehealth Profesional Evaluation Committee
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  • Invited Speaker
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    I have been invited to over 32 speaking engagements.  The following is the latest 10.
    1. Animal Science Department, Brigham Young University-Idaho,Rexburg, Idaho. "Stem cell research and its application in livestock species". November 16, 2005.
    2. American Association for the Advancement of Science, Pacific Division, "Gene Expression Patterns in Nuclear Transfer Embryos Compared to In Vitro Produced Control Embryos", June 15, 2004.
    3. Hillcrest Hospital, Tulsa, OK. "Stem cell research and Parkinson's disease", Fourth Annual American Parkinson's Disease Symposium, October 18, 2003.
    4. Oral Roberts University, Tulsa, OK. "Stem cells: embryonic and adult", April 18, 2003.
    5. Oral Roberts University, Tulsa, OK. "Cloning of mammals via nuclear transplantation", April 16, 2003.
    6. Taught hand-on laboratory on "Mammalian cloning via nuclear transplantation", at OSU-Stillwater, May 1, 2002.
    7. Oklahoma State University - Stillwater, OK, Honors Biology.  February 13, 2002. "Stem Cell Biology" at OSU-Stillwater, February 13, 2002.
    8. Oklahoma State University - Stillwater, OK.  February 13, 2002.  "Nuclear Remodeling:  Reprogramming Gene Expression".
    9. 10th annual Ethics and Aging Conference, Tulsa, OK.  October 11, 2002.  "Genetic Modification of Aging: Myth or Reality".
    10. Hillcrest Healthcare System, Parkinson's Seminar Series, September 12, 2002. "Stem Cell Research: Is it the answer we've been waiting for?"
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  • National and International Presentations
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    I have over 28 National and International Presentations, the following are the latest 10.

    1. Urick, K., J.M. Young, Rickords, L.F. "Induced apoptosis of breast carcinoma cells following transduction of E2F-1 Tat fusion proteins and activation of the p73 tumor suppressor pathway".  Presented at the American Association for Cancer Research, 96th annual meeting, Anaheim, CA.  April 16-20, 2005.
    2. Urick, K. and Rickords, L.F. (2005) "Transduction of E2F-1 Tat Fusion Proteins Activates the p73 and p21Waf1 Tumor Suppressor Pathways in p53-Mutated Breast Carcinoma Cells".  First Annual Conference for Duel-Degree Osteopathic Medicine, East Lansing, Michigan.  June 17-18, 2005.
    3. B.J. Pate, K.L. White, D.B. DeWald, Rickords, L.F., G. Li, K.I. Aston, B.R.Sessions, T.D. Bunch. (2005).  Involvement of Tyrosine Kinases, Specifically Src Family Kinases, Focal Adhesion Kinase (Fak), and Agonist-Induced PLC in the Activation and Development of Bovine Oocytes.  Mol Biol Cell 16:2739.
    4. Spencer, D.B., J.W. Ross, R.D. Geisert, Rickords, L.F.  2004.  Detection of Oct-4 gene expression in porcine conceptuses during preimplantation development.  Biol. Reprod. 71(suppl. 1):255.
    5. Pate, B.J., G.P. Li, K.I. Aston, T.D. Bunch, K.D. Campbell, D.S. Hammon, Rickords, L.F., K.L. White.  2004.  Specific integrin subunits present on the vitelline membrane of bovine oocytes.  Biol. Reprod. 71(suppl.1):237.
    6. Pedersen, H.G., Z. Rasmussen, D. Viuff, P.D. Thomsen, Rickords, L.F., L. Lai, R.S. Prather, T. Greve.  2003.  Chromosome abnormalities of in vivo developed, in vitro produced or parthenogentically activated porcine embryos.  Theriogenology 59:430.
    7. Adames, H.J., Rickords, L.F.  2002.  DNA Polymorphisms in the Y-Specific Amelogenin-Like Gene (AMELY) of Brown Tufted Capuchin and Pigtail, Japanese and Rhesus Macaques.  Biol. Reprod. 66(suppl 1):254.
    8. Viuff, D., Rickords, L.F., L. Lai, H.T. Cheong, M. Samuel, R.S. Prather, T. Greve, P.D. Thomsen. 2002.  The activation of ribosomal RNA genes in nuclear Transfer porcine embryos.  Theriogenology 57:455.
    9. Sands, S.S., Rickords, L.F., J. Hayashi, R.J. Ketchum 2001.  Thymic epithelial cells induce specific tolerance upon intrathymic transplantation, and may be transduced with genes encoding novel proteins, resulting in novel gene expression.  Cell Transplantation 10(6):24.
    10. Rickords, L.F., H.J. Adams.  2001.  DNA polymorphisms of the AMELX and AMELY Genes.  Symposium on: "Oocyte, embryo, fetus,newborn", Copenhagen, Denmark.
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  • Awards
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    • Undergraduate Research Mentor of the Year fr the College of Agriculture (2009)
    • Selected as the College of Agriculture faculty escort by the valedictorian for the December 2009 commencement (2009)
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