The third floor of the VSB contains four fully equipped microbiology laboratories (including BSL-3 facilities), a cell culture laboratory, a drug preparation laboratory, and a glassware sterilization/preparation room. These facilities are shared by the Department's microbiology, parasitology and virology programs. The first floor contains three additional microbiology laboratories used by the parasitology, toxicology and virology programs, and an electron microscope facility.

The older section of VSB contains laboratories for antibacterial, antifungal, and scrapie research programs.  Several rooms are used for the storage of research supplies. The building is located North of the Biology and Natural Resources building.